1-[3,5-bis(trifluoromethyl)phenyl]-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol

Base Information

Chemical Name:1-[3,5-bis(trifluoromethyl)phenyl]-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol
CAS No.:875443-89-3
Molecular Formula:C₂₈H₂₆F₉NO₂
Molecular Weight:579.506
Hs Code.:

Synonyms:1-[3,5-bis(trifluoromethyl)phenyl]-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol

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Chemical Property of 1-[3,5-bis(trifluoromethyl)phenyl]-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol

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Technology Process of 1-[3,5-bis(trifluoromethyl)phenyl]-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol

There total 5 articles about 1-[3,5-bis(trifluoromethyl)phenyl]-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 868166-22-7
1-[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methanamine

: 109086-18-2
2-[3,5-bis(trifluoromethyl)phenyl]oxirane

: 875443-89-3
1-[3,5-bis(trifluoromethyl)phenyl]-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol

Guidance literature:: In isopropyl alcohol; for 15h; regioselective reaction; Reflux;
DOI:10.1021/ml100309n

Reference yield:

: 868166-20-5
2-iodo-5-(trifluoromethyl)benzonitrile

: 875443-89-3
1-[3,5-bis(trifluoromethyl)phenyl]-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 2-Methyl-1,2-propanediol; ethanol; water / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

1.2: 0.17 h / 150 °C / Microwave irradiation

2.1: lithium aluminium tetrahydride / diethyl ether / 6 h / 0 - 20 °C

3.1: isopropyl alcohol / 15 h / Reflux

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 2-Methyl-1,2-propanediol; diethyl ether; ethanol; water; isopropyl alcohol;
DOI:10.1021/ml100309n

Reference yield:

: 6526-08-5
2-amino-5-(trifluoromethyl)benzonitrile

: 875443-89-3
1-[3,5-bis(trifluoromethyl)phenyl]-2-({[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}amino)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butylnitrite; diiodomethane / 0.5 h / 100 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 2-Methyl-1,2-propanediol; ethanol; water / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

2.2: 0.17 h / 150 °C / Microwave irradiation

3.1: lithium aluminium tetrahydride / diethyl ether / 6 h / 0 - 20 °C

4.1: isopropyl alcohol / 15 h / Reflux

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; diiodomethane; sodium carbonate; In 2-Methyl-1,2-propanediol; diethyl ether; ethanol; water; isopropyl alcohol;
DOI:10.1021/ml100309n