[18F]-N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-fluoropyridine-4-carboxamide

Base Information

Chemical Name:[18F]-N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-fluoropyridine-4-carboxamide
CAS No.:1215855-74-5
Molecular Formula:C₂₄H₂₄FN₅O₃
Molecular Weight:448.486
Hs Code.:

Synonyms:[18F]-N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-fluoropyridine-4-carboxamide

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Chemical Property of [18F]-N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-fluoropyridine-4-carboxamide

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Technology Process of [18F]-N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-fluoropyridine-4-carboxamide

There total 8 articles about [18F]-N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-fluoropyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1322094-88-1
N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-iodopyridine-4-carboxamide

: 1215855-74-5
[18F]-N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-fluoropyridine-4-carboxamide

Guidance literature:: With tetra(n-butyl)ammonium hydroxide; potassium carbonate; In water; acetonitrile; at 80 - 120 ℃; for 0.1h; Radiochemical reaction;

N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-iodopyridine-4-carboxamide; In dimethyl sulfoxide; at 180 ℃; for 0.333333h; Product distribution / selectivity; Radiochemical reaction;

Reference yield: 15.5%

: 1215855-73-4
N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-bromopyridine-4-carboxamide

: 1215855-74-5
[18F]-N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-fluoropyridine-4-carboxamide

Guidance literature:: With tetra(n-butyl)ammonium hydroxide; potassium carbonate; In water; acetonitrile; at 80 - 120 ℃; for 0.1h; Radiochemical reaction;

N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-bromopyridine-4-carboxamide; In dimethyl sulfoxide; at 180 ℃; for 0.333333h; Product distribution / selectivity; Radiochemical reaction;

Reference yield:

: 100-39-0
benzyl bromide

: 1215855-74-5
[18F]-N-(2-{4-[5-(benzyloxy)pyridin-2-yl]piperazin-1-yl}-2-oxoethyl)-2-fluoropyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 60 °C

2.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene; tetrahydrofuran / 20 °C / Reflux

3.1: dichloromethane; tetrahydrofuran / -10 - 20 °C

4.1: hydrogenchloride / diethyl ether / 20 °C

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

6.1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / acetonitrile; water / 0.1 h / 80 - 120 °C / Radiochemical reaction

6.2: 0.33 h / 180 °C / Radiochemical reaction

With hydrogenchloride; tetra(n-butyl)ammonium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;