tert-butyl 4-(4-fluoro-5-nitro-2-vinylbenzamido)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-fluoro-5-nitro-2-vinylbenzamido)piperidine-1-carboxylate
CAS No.:1202389-37-4
Molecular Formula:C₁₉H₂₄FN₃O₅
Molecular Weight:393.415
Hs Code.:

Synonyms:tert-butyl 4-(4-fluoro-5-nitro-2-vinylbenzamido)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-fluoro-5-nitro-2-vinylbenzamido)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of tert-butyl 4-(4-fluoro-5-nitro-2-vinylbenzamido)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-(4-fluoro-5-nitro-2-vinylbenzamido)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6336-45-4
vinylboronic acid dibutyl ester

: 1202389-36-3
tert-butyl 4-(2-chloro-4-fluoro-5-nitrobenzamido)piperidine-1-carboxylate

: 1202389-37-4
tert-butyl 4-(4-fluoro-5-nitro-2-vinylbenzamido)piperidine-1-carboxylate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; at 90 ℃; Inert atmosphere;

Reference yield:

: 114776-15-7
2-chloro-4-fluoro-5-nitrobenzoic acid

: 1202389-37-4
tert-butyl 4-(4-fluoro-5-nitro-2-vinylbenzamido)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 20 °C

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 90 °C / Inert atmosphere

With thionyl chloride; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 120890-66-6
2-chloro-4-fluoro-5-nitrobenzoyl chloride

: 1202389-37-4
tert-butyl 4-(4-fluoro-5-nitro-2-vinylbenzamido)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 90 °C / Inert atmosphere

With sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water;