(2S,5S)-5-aminopiperidine-1,2,5-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester

Base Information

Chemical Name:(2S,5S)-5-aminopiperidine-1,2,5-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester
CAS No.:862177-22-8
Molecular Formula:C₁₉H₂₆N₂O₆
Molecular Weight:378.425
Hs Code.:

Synonyms:(2S,5S)-5-aminopiperidine-1,2,5-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester

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Chemical Property of (2S,5S)-5-aminopiperidine-1,2,5-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester

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Technology Process of (2S,5S)-5-aminopiperidine-1,2,5-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester

There total 3 articles about (2S,5S)-5-aminopiperidine-1,2,5-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 862177-21-7
(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.5]decane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tert-butyl ester

: 862177-22-8
(2S,5S)-5-aminopiperidine-1,2,5-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/ol0507672

Reference yield:

: 147489-30-3
(2S)-5-oxopiperidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

: 862177-22-8
(2S,5S)-5-aminopiperidine-1,2,5-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: KCN / dimethylformamide; H₂O / 4 h / 60 °C

2: 2.6 g / DMAP / tetrahydrofuran / 3 h / 20 °C

3: 91 percent / aq. KOH / tetrahydrofuran / 0.5 h / 20 °C

With dmap; potassium cyanide; potassium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1: Bucherer-Bergs reaction;
DOI:10.1021/ol0507672

Reference yield:

: (8S)-2,4-dioxo-1,3,7-triazaspiro[4.5]decane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester

: 862177-22-8
(2S,5S)-5-aminopiperidine-1,2,5-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2.6 g / DMAP / tetrahydrofuran / 3 h / 20 °C

2: 91 percent / aq. KOH / tetrahydrofuran / 0.5 h / 20 °C

With dmap; potassium hydroxide; In tetrahydrofuran;
DOI:10.1021/ol0507672