C₃₈H₅₉N₅O₇S

Base Information

• Chemical Name: C₃₈H₅₉N₅O₇S
• CAS No.: 1357008-06-0
• Molecular Formula: C₃₈H₅₉N₅O₇S
• Molecular Weight: 729.982
• Mol file: 1357008-06-0.mol

Synonyms:C₃₈H₅₉N₅O₇S

Chemical Property of C₃₈H₅₉N₅O₇S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₈H₅₉N₅O₇S

There total 15 articles about C₃₈H₅₉N₅O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → C38H59N5O7S (1357008-06-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: dihydrogen peroxide; lithium hydroxide / methanol / 0 °C

2.2: pH 1

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: dihydrogen peroxide; lithium hydroxide / methanol / 0 °C

4.2: pH 1

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With dihydrogen peroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; dichloromethane;

DOI:10.1016/j.tet.2011.11.089

Reference yield:

C16H28N2O4S → C38H59N5O7S (1357008-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; triethylamine; trifluoroacetic anhydride / 1,2-dimethoxyethane / 0 °C / Inert atmosphere

2: methoxybenzene; trifluoroacetic acid / dichloromethane / 0.67 h

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With pyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; In 1,2-dimethoxyethane; dichloromethane;

DOI:10.1016/j.tet.2011.11.089

Reference yield:

methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate (1357008-65-1) → C38H59N5O7S (1357008-06-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: methoxybenzene; trifluoroacetic acid / dichloromethane / 0.67 h

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

3.1: dihydrogen peroxide; lithium hydroxide / methanol / 0 °C

3.2: pH 1

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With dihydrogen peroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane;

DOI:10.1016/j.tet.2011.11.089

upstream raw materials:

methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate

H-Phe-NMe-Leu-OMe

N-tert-butoxycarbonyl-(L)-leucinamide

N-tert-butoxycarbonyl-L-leucine

Downstream raw materials:

C₃₆H₅₅N₅O₇S

C₃₁H₄₇N₅O₅S

C₃₁H₄₅N₅O₄S

Refernces