(S)-3-(2-fluorophenyl)-3-[5,6,6-trimethyl-5-(2'-methylbiphenyl-4-yl)-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]propan-1-ol

Base Information

Chemical Name:(S)-3-(2-fluorophenyl)-3-[5,6,6-trimethyl-5-(2'-methylbiphenyl-4-yl)-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]propan-1-ol
CAS No.:1397713-09-5
Molecular Formula:C₂₈H₃₁FN₂O₄S
Molecular Weight:510.63
Hs Code.:

Synonyms:(S)-3-(2-fluorophenyl)-3-[5,6,6-trimethyl-5-(2'-methylbiphenyl-4-yl)-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]propan-1-ol

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Chemical Property of (S)-3-(2-fluorophenyl)-3-[5,6,6-trimethyl-5-(2'-methylbiphenyl-4-yl)-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]propan-1-ol

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Technology Process of (S)-3-(2-fluorophenyl)-3-[5,6,6-trimethyl-5-(2'-methylbiphenyl-4-yl)-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]propan-1-ol

There total 6 articles about (S)-3-(2-fluorophenyl)-3-[5,6,6-trimethyl-5-(2'-methylbiphenyl-4-yl)-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1397714-76-9
[5-(4-bromophenyl)-5,6,6-trimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-yl]-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(2-fluorophenyl)propyl]amine

: 16419-60-6
2-Methylphenylboronic acid

: 1397713-09-5
(S)-3-(2-fluorophenyl)-3-[5,6,6-trimethyl-5-(2'-methylbiphenyl-4-yl)-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]propan-1-ol

Guidance literature:: [5-(4-bromophenyl)-5,6,6-trimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-yl]-[(S)-3-(tert-butyldimethylsilanyloxy)-1-(2-fluorophenyl)propyl]amine; 2-Methylphenylboronic acid; With caesium carbonate; In 1,4-dioxane; water; for 0.333333h; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 80 ℃; for 0.75h;

With hydrogenchloride; In methanol; water;

Reference yield:

: 151911-32-9,151911-22-7
(S)-3-amino-3-(2'-fluorophenyl)propanoic acid

: 1397713-09-5
(S)-3-(2-fluorophenyl)-3-[5,6,6-trimethyl-5-(2'-methylbiphenyl-4-yl)-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 50 °C / Inert atmosphere

1.2: 0.17 h

1.3: 20 °C

2.1: dichloromethane / 20 °C / Inert atmosphere

3.1: caesium carbonate / water; 1,4-dioxane / 0.33 h / Inert atmosphere

3.2: 0.75 h / 80 °C

With lithium aluminium tetrahydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1397715-46-6
N-[2,4-dimethoxybenzyl]-1-(4-bromophenyl)ethanesulfonamide

: 1397713-09-5
(S)-3-(2-fluorophenyl)-3-[5,6,6-trimethyl-5-(2'-methylbiphenyl-4-yl)-4,4-dioxo-5,6-dihydro-4H-4lambda6-[1,4,3]-oxathiazin-2-ylamino]propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: methyllithium / tetrahydrofuran; diethyl ether / 0.17 h / -78 °C / Inert atmosphere

1.2: 0.25 h

1.3: 1 h / 20 °C

2.1: acetic acid / water / 1.5 h / 100 °C

3.1: dichloromethane / 20 °C / Inert atmosphere

4.1: caesium carbonate / water; 1,4-dioxane / 0.33 h / Inert atmosphere

4.2: 0.75 h / 80 °C

With methyllithium; caesium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water;