(S)-1,1-dimethylethyl 2-<<4-amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate

Base Information

Chemical Name:(S)-1,1-dimethylethyl 2-<<4-amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate
CAS No.:135697-11-9
Molecular Formula:C₂₂H₂₆N₄O₅
Molecular Weight:426.472
Hs Code.:

(S)-1,1-dimethylethyl 2-<<4-<benzoyl<(1,1-dimethylethoxy)carbonyl>amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate

Synonyms:(S)-1,1-dimethylethyl 2-<<4-amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate

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Chemical Property of (S)-1,1-dimethylethyl 2-<<4-amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate

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Technology Process of (S)-1,1-dimethylethyl 2-<<4-amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate

There total 6 articles about (S)-1,1-dimethylethyl 2-<<4-amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 135697-08-4
(S)-N-<1,2-dihydro-2-oxo-1-<(6-oxo-2-piperidinyl)methyl>-4-pyrimidinyl>benzamide

: 135697-11-9
(S)-1,1-dimethylethyl 2-<<4-amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 25 ℃; for 2h;
DOI:10.1021/jo00021a010

Reference yield:

: 98-88-4
benzoyl chloride

: 135697-11-9
(S)-1,1-dimethylethyl 2-<<4-amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / pyridine / 8 h

2: 69 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 25 °C

With pyridine; dmap; triethylamine; In dichloromethane;
DOI:10.1021/jo00021a010

Reference yield:

: 128726-47-6
(+)-(S)-6-hydroxymethyl-2-piperidinone

: 135697-11-9
(S)-1,1-dimethylethyl 2-<<4-amino>-1,2-dihydro-2-oxo-1-pyrimidinyl>methyl>-6-oxo-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 70.4 percent / N-methylimidazole / CH₂Cl₂ / 24 h / 0 °C

2: 88 percent / potassium tert-butoxide / dimethylsulfoxide / 8 h / 50 °C

3: 50 percent / pyridine / 8 h

4: 69 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 25 °C

With pyridine; 1-methyl-1H-imidazole; dmap; potassium tert-butylate; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00021a010