(R)-2-Allyl-6-oxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:(R)-2-Allyl-6-oxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:74965-55-2
Molecular Formula:C₂₀H₃₂O₃
Molecular Weight:320.472
Hs Code.:

Synonyms:(R)-2-Allyl-6-oxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Chemical Property of (R)-2-Allyl-6-oxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Technology Process of (R)-2-Allyl-6-oxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 4 articles about (R)-2-Allyl-6-oxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2216-51-5
(-)-menthol

: 74965-55-2
(R)-2-Allyl-6-oxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / triethylamine / acetone / 2 h / Heating

2: 1) 50percent NaH, 2) BuLi / 1) THF, 0 deg C, 15 min; 2) hexane, 30 min, 0 deg C

3: 1) p-toluenesulfonyl azide, TEA, 2) copper bronze powder / 1) room temperature overnight; 2) toluene,1h, reflux

4: 1) BuLi, 2) CuI, Me₂S / 1) THF, hexane, o deg C; 2) -35 deg C; 3) THF, 10 min

With copper(l) iodide; n-butyllithium; 4-toluenesulfonyl azide; dimethylsulfide; TEA; copper; sodium hydride; triethylamine; In acetone;
DOI:10.1021/jo01311a031

Reference yield:

: 74965-53-0
3-Oxo-oct-7-enoic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: 74965-55-2
(R)-2-Allyl-6-oxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) p-toluenesulfonyl azide, TEA, 2) copper bronze powder / 1) room temperature overnight; 2) toluene,1h, reflux

2: 1) BuLi, 2) CuI, Me₂S / 1) THF, hexane, o deg C; 2) -35 deg C; 3) THF, 10 min

With copper(l) iodide; n-butyllithium; 4-toluenesulfonyl azide; dimethylsulfide; TEA; copper;
DOI:10.1021/jo01311a031

Reference yield:

: 59557-05-0
(L)-menthyl 3-oxobutyrate

: 74965-55-2
(R)-2-Allyl-6-oxo-cyclohexanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) 50percent NaH, 2) BuLi / 1) THF, 0 deg C, 15 min; 2) hexane, 30 min, 0 deg C

2: 1) p-toluenesulfonyl azide, TEA, 2) copper bronze powder / 1) room temperature overnight; 2) toluene,1h, reflux

3: 1) BuLi, 2) CuI, Me₂S / 1) THF, hexane, o deg C; 2) -35 deg C; 3) THF, 10 min

With copper(l) iodide; n-butyllithium; 4-toluenesulfonyl azide; dimethylsulfide; TEA; copper; sodium hydride;
DOI:10.1021/jo01311a031