4-(pyridin-3-yl)-N-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)pyrimidin-2-amine,trifluroacetic acid salt

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Chemical Name:4-(pyridin-3-yl)-N-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)pyrimidin-2-amine,trifluroacetic acid salt
CAS No.:1433205-40-3
Molecular Formula:C₁₉H₁₃F₃N₆O
Molecular Weight:398.347
Hs Code.:

Synonyms:4-(pyridin-3-yl)-N-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)pyrimidin-2-amine,trifluroacetic acid salt

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Chemical Property of 4-(pyridin-3-yl)-N-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)pyrimidin-2-amine,trifluroacetic acid salt

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Technology Process of 4-(pyridin-3-yl)-N-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)pyrimidin-2-amine,trifluroacetic acid salt

There total 4 articles about 4-(pyridin-3-yl)-N-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)pyrimidin-2-amine,trifluroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.95%

: 510771-81-0
(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)methanamine

: 483324-01-2
2-chloro-4-(pyridin-3-yl)pyrimidine

: 1433205-40-3
4-(pyridin-3-yl)-N-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)pyrimidin-2-amine,trifluroacetic acid salt

Guidance literature:: With N,N-dimethyl acetamide; triethylamine; at 160 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 66389-80-8
tert-butyl N-[(4-cyanophenyl)methyl]carbamate

: 1433205-40-3
4-(pyridin-3-yl)-N-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)pyrimidin-2-amine,trifluroacetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; hydroxylamine hydrochloride / ethanol / 4 h / 90 °C

2: dmap / tetrahydrofuran / 3 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: N,N-dimethyl acetamide; triethylamine / 0.17 h / 160 °C / Microwave irradiation

With hydrogenchloride; dmap; N,N-dimethyl acetamide; hydroxylamine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 1456610-74-4,220648-78-2
N-Boc-4-aminomethyl-N-hydroxy-benzamidine

: 1433205-40-3
4-(pyridin-3-yl)-N-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl)pyrimidin-2-amine,trifluroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / tetrahydrofuran / 3 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: N,N-dimethyl acetamide; triethylamine / 0.17 h / 160 °C / Microwave irradiation

With hydrogenchloride; dmap; N,N-dimethyl acetamide; triethylamine; In tetrahydrofuran; 1,4-dioxane;