(S)-3-(2-methoxyphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Base Information

Chemical Name:(S)-3-(2-methoxyphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide
CAS No.:1582806-70-9
Molecular Formula:C₂₅H₁₅F₇N₂O₄
Molecular Weight:540.394
Hs Code.:

Synonyms:(S)-3-(2-methoxyphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(2-methoxyphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

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Technology Process of (S)-3-(2-methoxyphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

There total 5 articles about (S)-3-(2-methoxyphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1582806-46-9
(S)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

: 376353-52-5
(2-methoxyphenyl)triethoxysilane

: 1582806-70-9
(S)-3-(2-methoxyphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: With palladium diacetate; silver fluoride; 8,9,10,11-tetrahydro-7H-cyclohepta[c]quinoline; In 1,4-dioxane; at 20 - 110 ℃; for 18h; Sealed tube;
DOI:10.1021/jacs.5b00890

Reference yield:

: 22509-74-6
N-ethoxycarbonylphthalimide

: 1582806-70-9
(S)-3-(2-methoxyphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / water / 3 h / 20 °C

2: thionyl chloride; N,N-dimethyl-formamide / toluene / 3 h / 80 °C

3: toluene / 12.5 h / 20 °C / Reflux

4: 8,9,10,11-tetrahydro-7H-cyclohepta[c]quinoline; palladium diacetate; silver fluoride / 1,4-dioxane / 18 h / 20 - 110 °C / Sealed tube

With thionyl chloride; palladium diacetate; silver fluoride; sodium carbonate; N,N-dimethyl-formamide; 8,9,10,11-tetrahydro-7H-cyclohepta[c]quinoline; In 1,4-dioxane; water; toluene;
DOI:10.1021/jacs.5b00890

Reference yield:

: 4306-25-6
(S)-2-phthalimidopropionyl chloride

: 1582806-70-9
(S)-3-(2-methoxyphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 12.5 h / 20 °C / Reflux

2: 8,9,10,11-tetrahydro-7H-cyclohepta[c]quinoline; palladium diacetate; silver fluoride / 1,4-dioxane / 18 h / 20 - 110 °C / Sealed tube

With palladium diacetate; silver fluoride; 8,9,10,11-tetrahydro-7H-cyclohepta[c]quinoline; In 1,4-dioxane; toluene;
DOI:10.1021/jacs.5b00890