p-iodophenyl 3,4-di-O-benzyl-2-O-methyl-α-L-rhamnopyranoside

Base Information

Chemical Name:p-iodophenyl 3,4-di-O-benzyl-2-O-methyl-α-L-rhamnopyranoside
CAS No.:1449576-21-9
Molecular Formula:C₂₇H₂₉IO₅
Molecular Weight:560.429
Hs Code.:

Synonyms:p-iodophenyl 3,4-di-O-benzyl-2-O-methyl-α-L-rhamnopyranoside

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of p-iodophenyl 3,4-di-O-benzyl-2-O-methyl-α-L-rhamnopyranoside

Chemical Property:

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Technology Process of p-iodophenyl 3,4-di-O-benzyl-2-O-methyl-α-L-rhamnopyranoside

There total 8 articles about p-iodophenyl 3,4-di-O-benzyl-2-O-methyl-α-L-rhamnopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1449576-20-8
p-iodophenyl 3,4-di-O-benzyl-α-L-rhamnopyranoside

: 74-88-4
methyl iodide

: 1449576-21-9
p-iodophenyl 3,4-di-O-benzyl-2-O-methyl-α-L-rhamnopyranoside

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h;
DOI:10.1002/ejoc.201300437

Reference yield:

: 6014-42-2
L-rhamnose

: 1449576-21-9
p-iodophenyl 3,4-di-O-benzyl-2-O-methyl-α-L-rhamnopyranoside

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / water / 16 h / 20 °C

2.1: acetic acid; acetic anhydride; hydrogen bromide

3.1: tetra-(n-butyl)ammonium iodide; 2,4,6-trimethyl-pyridine / 8 h / 80 °C

4.1: potassium hydroxide / tetrahydrofuran / 8 h / Reflux

5.1: acetic acid / water / 16 h / 20 °C

5.2: 0 °C

5.3: 1.5 h

6.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / -45 - 20 °C

7.1: methanol; sodium methylate / 24 h / 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

With pyridine; 2,4,6-trimethyl-pyridine; methanol; trimethylsilyl trifluoromethanesulfonate; hydrogen bromide; sodium methylate; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/ejoc.201300437

Reference yield:

: 30021-94-4
1,2,3,4-O-tetraacetyl-α-L-rhamnopyranose

: 1449576-21-9
p-iodophenyl 3,4-di-O-benzyl-2-O-methyl-α-L-rhamnopyranoside

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid; acetic anhydride; hydrogen bromide

2.1: tetra-(n-butyl)ammonium iodide; 2,4,6-trimethyl-pyridine / 8 h / 80 °C

3.1: potassium hydroxide / tetrahydrofuran / 8 h / Reflux

4.1: acetic acid / water / 16 h / 20 °C

4.2: 0 °C

4.3: 1.5 h

5.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / -45 - 20 °C

6.1: methanol; sodium methylate / 24 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

With 2,4,6-trimethyl-pyridine; methanol; trimethylsilyl trifluoromethanesulfonate; hydrogen bromide; sodium methylate; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/ejoc.201300437