N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-5-chlorophenyl)but-2-ynamide trifluoroacetate

Base Information

Chemical Name:N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-5-chlorophenyl)but-2-ynamide trifluoroacetate
CAS No.:1431959-33-9
Molecular Formula:C₂HF₃O₂*C₂₀H₁₈ClN₅OS
Molecular Weight:525.939
Hs Code.:

Synonyms:N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-5-chlorophenyl)but-2-ynamide trifluoroacetate

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Chemical Property of N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-5-chlorophenyl)but-2-ynamide trifluoroacetate

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Technology Process of N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-5-chlorophenyl)but-2-ynamide trifluoroacetate

There total 5 articles about N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-5-chlorophenyl)but-2-ynamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 590-93-2
2-Butynoic acid

: C₁₆H₁₆ClN₅S

: 76-05-1
trifluoroacetic acid

: 1431959-33-9
N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-5-chlorophenyl)but-2-ynamide trifluoroacetate

Guidance literature:: 2-Butynoic acid; With triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

C₁₆H₁₆ClN₅S; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 888498-07-5
(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine

: 1431959-33-9
N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-5-chlorophenyl)but-2-ynamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; dmap / methanol / 0.5 h / 20 °C / Cooling with ice

1.2: 1.58 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 1 h / 20 °C

3.1: triethylamine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 4 h / 20 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 38487-86-4
2-amino-4-chlorobenzonitrile

: 1431959-33-9
N-(2-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-5-chlorophenyl)but-2-ynamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / Reflux; Inert atmosphere

2.1: triethylamine / dichloromethane / 1 h / 20 °C

3.1: triethylamine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 4 h / 20 °C

With dimethylsulfide borane complex; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;