(2S,3R)-2-Benzyloxycarbonylamino-3-hydroxy-butyric acid (1S,2R,3R)-3-dibenzoylaminocarbonyl-1-methyl-2-(3-methyl-butyryloxy)-heptyl ester

Base Information

Chemical Name:(2S,3R)-2-Benzyloxycarbonylamino-3-hydroxy-butyric acid (1S,2R,3R)-3-dibenzoylaminocarbonyl-1-methyl-2-(3-methyl-butyryloxy)-heptyl ester
CAS No.:94820-29-8
Molecular Formula:C₄₀H₄₈N₂O₁₀
Molecular Weight:716.829
Hs Code.:

Synonyms:(2S,3R)-2-Benzyloxycarbonylamino-3-hydroxy-butyric acid (1S,2R,3R)-3-dibenzoylaminocarbonyl-1-methyl-2-(3-methyl-butyryloxy)-heptyl ester

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Chemical Property of (2S,3R)-2-Benzyloxycarbonylamino-3-hydroxy-butyric acid (1S,2R,3R)-3-dibenzoylaminocarbonyl-1-methyl-2-(3-methyl-butyryloxy)-heptyl ester

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Technology Process of (2S,3R)-2-Benzyloxycarbonylamino-3-hydroxy-butyric acid (1S,2R,3R)-3-dibenzoylaminocarbonyl-1-methyl-2-(3-methyl-butyryloxy)-heptyl ester

There total 11 articles about (2S,3R)-2-Benzyloxycarbonylamino-3-hydroxy-butyric acid (1S,2R,3R)-3-dibenzoylaminocarbonyl-1-methyl-2-(3-methyl-butyryloxy)-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94820-28-7
(+)-(1R,2R,3S)-2-(3-(N-benzyloxycarbonyl-L-threonyloxy)-1-n-butyl-2-isobutylcarbonyloxybutyl)-4,5-diphenyloxazole

: 94820-29-8
(2S,3R)-2-Benzyloxycarbonylamino-3-hydroxy-butyric acid (1S,2R,3R)-3-dibenzoylaminocarbonyl-1-methyl-2-(3-methyl-butyryloxy)-heptyl ester

Guidance literature:: With Sensitox; oxygen; In dichloromethane; at 25 ℃; for 3h;
DOI:10.1021/ja00291a059

Reference yield:

: 14224-99-8
2-methyl-4,5-diphenyloxazole

: 94820-29-8
(2S,3R)-2-Benzyloxycarbonylamino-3-hydroxy-butyric acid (1S,2R,3R)-3-dibenzoylaminocarbonyl-1-methyl-2-(3-methyl-butyryloxy)-heptyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / n-BiLi / tetrahydrofuran / -78 °C

2: 1) n-BuLi / 1) THF, -78 deg C

3: 74 percent / pyridine

4: 57 percent / boron trifluoride etherate, thiophenol

5: 95 percent / DCC, DMAP / CH₂Cl₂

6: 64 percent / n-Bu₄NF / tetrahydrofuran / 0 °C

7: O₂, Sensitox / CH₂Cl₂ / 3 h / 25 °C

With pyridine; dmap; n-butyllithium; Sensitox; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; oxygen; thiophenol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00291a059

Reference yield:

: 20662-96-8
2-n-pentyl-4,5-diphenyloxazole

: 94820-29-8
(2S,3R)-2-Benzyloxycarbonylamino-3-hydroxy-butyric acid (1S,2R,3R)-3-dibenzoylaminocarbonyl-1-methyl-2-(3-methyl-butyryloxy)-heptyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1) n-BuLi / 1) THF, -78 deg C

2: 74 percent / pyridine

3: 57 percent / boron trifluoride etherate, thiophenol

4: 95 percent / DCC, DMAP / CH₂Cl₂

5: 64 percent / n-Bu₄NF / tetrahydrofuran / 0 °C

6: O₂, Sensitox / CH₂Cl₂ / 3 h / 25 °C

With pyridine; dmap; n-butyllithium; Sensitox; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; oxygen; thiophenol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00291a059