(R)-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-acetaldehyde

Base Information

Chemical Name:(R)-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-acetaldehyde
CAS No.:392250-80-5
Molecular Formula:C₁₅H₂₀O₅
Molecular Weight:280.321
Hs Code.:

Synonyms:(R)-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-acetaldehyde

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Chemical Property of (R)-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-acetaldehyde

Chemical Property:

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Technology Process of (R)-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-acetaldehyde

There total 4 articles about (R)-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethanol

: 392250-80-5
(R)-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-acetaldehyde

Guidance literature:: (2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[(4-methoxybenzyl)oxy]ethanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/hlca.201500110

Reference yield:

: 68572-75-8
diethyl (4R,5R)-2-(4-methoxyphenyl)-1,3-dioxolane-4,5-dicarboxylate

: 392250-80-5
(R)-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran; dichloromethane / 3 h / 20 °C / Inert atmosphere; Reflux

2.1: toluene-4-sulfonic acid / acetone / 1 h / -60 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; acetone; 3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1002/hlca.201500110

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 392250-80-5
(R)-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 8 h / Reflux; Dean-Stark; Inert atmosphere

2.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran; dichloromethane / 3 h / 20 °C / Inert atmosphere; Reflux

3.1: toluene-4-sulfonic acid / acetone / 1 h / -60 °C / Inert atmosphere

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C / Inert atmosphere

4.2: 0.5 h / -78 °C / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; acetone; toluene; 4.1: |Swern Oxidation / 4.2: |Swern Oxidation;
DOI:10.1002/hlca.201500110