N-(4-acrylamidophenethyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

Base Information

Chemical Name:N-(4-acrylamidophenethyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide
CAS No.:1276107-33-5
Molecular Formula:C₂₉H₂₇N₇O₃S
Molecular Weight:553.644
Hs Code.:

Synonyms:N-(4-acrylamidophenethyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

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Chemical Property of N-(4-acrylamidophenethyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

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Technology Process of N-(4-acrylamidophenethyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

There total 7 articles about N-(4-acrylamidophenethyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956389-20-1
2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid

: 1276109-82-0
N-(4-(2-aminoethyl)phenyl)acrylamide trifluoroacetate

: 1276107-33-5
N-(4-acrylamidophenethyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

Guidance literature:: With 2-chloro-1,3-dimethyl-4,5-dihydro-1H-imidazolium chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl acetamide; for 0.0833333h;

Reference yield:

: 16234-14-3
2,4-dichlorothieno[3,2-d]pyrimidine

: 1276107-33-5
N-(4-acrylamidophenethyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 1 h / 20 °C

2.1: n-butyllithium / n-heptane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl acetamide / 0.5 h / 120 °C / Microwave irradiation

5.1: N-ethyl-N,N-diisopropylamine; 2-chloro-1,3-dimethyl-4,5-dihydro-1H-imidazolium chloride / dichloromethane; N,N-dimethyl acetamide / 0.08 h

With n-butyllithium; 2-chloro-1,3-dimethyl-4,5-dihydro-1H-imidazolium chloride; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; n-heptane; dichloromethane; N,N-dimethyl acetamide; water; 4.1: Suzuki Coupling;

Reference yield:

: 956388-76-4
2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid

: 1276107-33-5
N-(4-acrylamidophenethyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl acetamide / 0.5 h / 120 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine; 2-chloro-1,3-dimethyl-4,5-dihydro-1H-imidazolium chloride / dichloromethane; N,N-dimethyl acetamide / 0.08 h

With 2-chloro-1,3-dimethyl-4,5-dihydro-1H-imidazolium chloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl acetamide; water; 1: Suzuki Coupling;