2-(1H-indazol-4-yl)-4-morpholino-N-(2-(4-propionamidophenyl)ethyl)thieno[3,2-d]pyrimidine-6-carboxamide

Base Information

Chemical Name:2-(1H-indazol-4-yl)-4-morpholino-N-(2-(4-propionamidophenyl)ethyl)thieno[3,2-d]pyrimidine-6-carboxamide
CAS No.:1276109-84-2
Molecular Formula:C₂₉H₂₉N₇O₃S
Molecular Weight:555.66
Hs Code.:

Synonyms:2-(1H-indazol-4-yl)-4-morpholino-N-(2-(4-propionamidophenyl)ethyl)thieno[3,2-d]pyrimidine-6-carboxamide

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Chemical Property of 2-(1H-indazol-4-yl)-4-morpholino-N-(2-(4-propionamidophenyl)ethyl)thieno[3,2-d]pyrimidine-6-carboxamide

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Technology Process of 2-(1H-indazol-4-yl)-4-morpholino-N-(2-(4-propionamidophenyl)ethyl)thieno[3,2-d]pyrimidine-6-carboxamide

There total 8 articles about 2-(1H-indazol-4-yl)-4-morpholino-N-(2-(4-propionamidophenyl)ethyl)thieno[3,2-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1276107-33-5
N-(4-acrylamidophenethyl)-2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

: 1276109-84-2
2-(1H-indazol-4-yl)-4-morpholino-N-(2-(4-propionamidophenyl)ethyl)thieno[3,2-d]pyrimidine-6-carboxamide

Guidance literature:: With hydrogen; 5%-palladium/activated carbon;

Reference yield:

: 956388-76-4
2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid

: 1276109-84-2
2-(1H-indazol-4-yl)-4-morpholino-N-(2-(4-propionamidophenyl)ethyl)thieno[3,2-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl acetamide / 0.5 h / 120 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine; 2-chloro-1,3-dimethyl-4,5-dihydro-1H-imidazolium chloride / dichloromethane; N,N-dimethyl acetamide / 0.08 h

3: hydrogen / 5%-palladium/activated carbon

With 2-chloro-1,3-dimethyl-4,5-dihydro-1H-imidazolium chloride; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; In dichloromethane; N,N-dimethyl acetamide; water; 1: Suzuki Coupling;

Reference yield:

: 94838-59-2
tert-butyl 4-aminophenethylcarbamate

: 1276109-84-2
2-(1H-indazol-4-yl)-4-morpholino-N-(2-(4-propionamidophenyl)ethyl)thieno[3,2-d]pyrimidine-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / -10 °C

2: dichloromethane / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; 2-chloro-1,3-dimethyl-4,5-dihydro-1H-imidazolium chloride / dichloromethane; N,N-dimethyl acetamide / 0.08 h

4: hydrogen / 5%-palladium/activated carbon

With 2-chloro-1,3-dimethyl-4,5-dihydro-1H-imidazolium chloride; hydrogen; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; In dichloromethane; N,N-dimethyl acetamide;