(2R)-2-{(2S)-2-[(R)-(1-aminophenyl)methyl]piperidin-1-yl}-2-phenylethanol

Base Information

Chemical Name:(2R)-2-{(2S)-2-[(R)-(1-aminophenyl)methyl]piperidin-1-yl}-2-phenylethanol
CAS No.:181872-24-2
Molecular Formula:C₂₀H₂₆N₂O
Molecular Weight:310.439
Hs Code.:

Synonyms:(2R)-2-{(2S)-2-[(R)-(1-aminophenyl)methyl]piperidin-1-yl}-2-phenylethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-{(2S)-2-[(R)-(1-aminophenyl)methyl]piperidin-1-yl}-2-phenylethanol

Chemical Property:

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Technology Process of (2R)-2-{(2S)-2-[(R)-(1-aminophenyl)methyl]piperidin-1-yl}-2-phenylethanol

There total 4 articles about (2R)-2-{(2S)-2-[(R)-(1-aminophenyl)methyl]piperidin-1-yl}-2-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 181872-21-9
(1S,4R,9aS)-1,4-Diphenyl-octahydro-pyrido[2,1-c][1,4]oxazin-1-ylamine

: 181872-24-2
(2R)-2-{(2S)-2-[(R)-(1-aminophenyl)methyl]piperidin-1-yl}-2-phenylethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 1.5h; Ambient temperature;
DOI:10.1021/jo960910s

Reference yield:

: 88056-92-2
(-)-2-cyano-6-phenyloxazolopiperidine

: 181872-24-2
(2R)-2-{(2S)-2-[(R)-(1-aminophenyl)methyl]piperidin-1-yl}-2-phenylethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / diethyl ether / 1.5 h / Ambient temperature

2: 75 percent / NaBH₃CN, 1 N HCl / methanol; tetrahydrofuran / 1.5 h / Heating; pH 3

3: 94 percent / LiAlH₄ / diethyl ether / 1.5 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; sodium cyanoborohydride; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo960910s

Reference yield:

: 591-51-5
phenyllithium

: 181872-24-2
(2R)-2-{(2S)-2-[(R)-(1-aminophenyl)methyl]piperidin-1-yl}-2-phenylethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / diethyl ether / 1.5 h / Ambient temperature

2: 75 percent / NaBH₃CN, 1 N HCl / methanol; tetrahydrofuran / 1.5 h / Heating; pH 3

3: 94 percent / LiAlH₄ / diethyl ether / 1.5 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; sodium cyanoborohydride; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo960910s