(S)-1-phenyl-2-propynylamine

Base Information

• Chemical Name: (S)-1-phenyl-2-propynylamine
• CAS No.: 226699-01-0
• Molecular Formula: C₉H₉N
• Molecular Weight: 131.177
• Mol file: 226699-01-0.mol

Synonyms:(S)-1-phenyl-2-propynylamine

Chemical Property of (S)-1-phenyl-2-propynylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-phenyl-2-propynylamine

There total 5 articles about (S)-1-phenyl-2-propynylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.2%

1-phenylprop-2-ynyl-1-amine (50874-15-2) + ethyl acetate (141-78-6) → (S)-1-phenyl-2-propynylamine (226699-01-0) + (R)-N-(α-phenylpropargyl)acetamide (868701-79-5)

Guidance literature:

With lipase B from Candida antarctica NOVOZYM 435; In diethyl ether; at 20 ℃; for 17h;

DOI:10.1021/jo982513i

Reference yield:

N-(α-phenylpropargyl)acetamide (123772-66-7) → (S)-1-phenyl-2-propynylamine (226699-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / 70 °C

2: CAL-B / diethyl ether / 20 °C / Enzymatic reaction; kinetic resolution of racemate

With hydrogenchloride; CAL-B; In diethyl ether;

DOI:10.1016/j.tetasy.2007.06.007

Reference yield:

1-Phenyl-2-propyn-1-ol (4187-87-5) → (S)-1-phenyl-2-propynylamine (226699-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 20 °C

2: HCl / 70 °C

3: CAL-B / diethyl ether / 20 °C / Enzymatic reaction; kinetic resolution of racemate

With hydrogenchloride; sulfuric acid; CAL-B; In diethyl ether; 1: Ritter reaction;

DOI:10.1016/j.tetasy.2007.06.007

upstream raw materials:

1-phenylprop-2-ynyl-1-amine

ethyl acetate

1-Phenyl-2-propyn-1-ol

N-(α-phenylpropargyl)acetamide

Downstream raw materials:

(S)-(+)-α-(2-benzofuranyl)benzylamine