2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethylamine

Base Information

Chemical Name:2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethylamine
CAS No.:959937-92-9
Molecular Formula:C₂₉H₄₃N₃O₅S
Molecular Weight:545.744
Hs Code.:

Synonyms:2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethylamine

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Chemical Property of 2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethylamine

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Technology Process of 2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethylamine

There total 23 articles about 2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959937-93-0
{2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethyl}carbamic acid benzyl ester

: 959937-92-9
2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h;

Reference yield:

: 959937-54-3
methyl 3-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionate

: 959937-92-9
2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; sodium hydroxide; water / tetrahydrofuran / 4 h / 20 - 60 °C

1.2: 20 °C

2.1: triethylamine / tetrahydrofuran / 1 h / 0 °C

3.1: sodium azide / tetrahydrofuran; water / 0.75 h / 0 °C

4.1: toluene / 2 h / 115 °C

5.1: 2 h / 120 °C

6.1: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C

With methanol; sodium hydroxide; sodium azide; water; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

: 857272-02-7
6-chloromethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 959937-92-9
2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 3 h / 20 °C

2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 4 h / 20 - 60 °C

2.2: 20 °C

3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C

4.1: sodium azide / tetrahydrofuran; water / 0.75 h / 0 °C

5.1: toluene / 2 h / 115 °C

6.1: 2 h / 120 °C

7.1: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C

With methanol; sodium hydroxide; sodium azide; water; hydrogen; tetra-(n-butyl)ammonium iodide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;