{2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethyl}carbamic acid benzyl ester

Base Information

Chemical Name:{2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethyl}carbamic acid benzyl ester
CAS No.:959937-93-0
Molecular Formula:C₃₇H₄₉N₃O₇S
Molecular Weight:679.878
Hs Code.:

{2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethyl}carbamic acid benzyl ester

Synonyms:{2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethyl}carbamic acid benzyl ester

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Chemical Property of {2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethyl}carbamic acid benzyl ester

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Technology Process of {2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethyl}carbamic acid benzyl ester

There total 21 articles about {2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethyl}carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959938-03-5
6-[(3R,6S)-6-(2-isocyanato-2-methylpropyl)-1-(toluene-4-sulphonyl)piperidin-3-yloxymethyl]-4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazine

: 100-51-6,185532-71-2
benzyl alcohol

: 959937-93-0
{2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethyl}carbamic acid benzyl ester

Guidance literature:: at 120 ℃; for 2h;

Reference yield:

: 959937-57-6
3-[(2S,5R)-5-(4-methoxybenzyloxy)-1-(toluene-4-sulphonyl)piperidin-2-yl]-2,2-dimethylpropionic acid methyl ester

: 959937-93-0
{2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethyl}carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h

2.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 3 h / 20 °C

3.1: methanol; sodium hydroxide; water / tetrahydrofuran / 4 h / 20 - 60 °C

3.2: 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / 0 °C

5.1: sodium azide / tetrahydrofuran; water / 0.75 h / 0 °C

6.1: toluene / 2 h / 115 °C

7.1: 2 h / 120 °C

With methanol; sodium hydroxide; sodium azide; water; hydrogen; tetra-(n-butyl)ammonium iodide; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 857272-02-7
6-chloromethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 959937-93-0
{2-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]-1,1-dimethyl-ethyl}carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 3 h / 20 °C

2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 4 h / 20 - 60 °C

2.2: 20 °C

3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C

4.1: sodium azide / tetrahydrofuran; water / 0.75 h / 0 °C

5.1: toluene / 2 h / 115 °C

6.1: 2 h / 120 °C

With methanol; sodium hydroxide; sodium azide; water; tetra-(n-butyl)ammonium iodide; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;