2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole

Base Information

Chemical Name:2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole
CAS No.:330666-86-9
Molecular Formula:C₂₆H₂₅NO₇
Molecular Weight:463.487
Hs Code.:

Synonyms:2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole

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Chemical Property of 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole

Chemical Property:

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Technology Process of 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole

There total 13 articles about 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 439585-92-9
2-(3′-isopropoxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole

: 330666-86-9
2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole

Guidance literature:: With aluminium trichloride; In dichloromethane; at 18 ℃; for 1h;
DOI:10.1021/jm020077t

Reference yield:

: 439585-86-1
4-ethynyl-2-isopropoxy-1-methoxybenzene

: 330666-86-9
2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; CuI / Pd(PPh₃)2Cl₂ / acetonitrile / 1 h / 18 °C

2: 73 percent / K₂CO₃ / acetonitrile / 18 h / 18 °C

3: 91 percent / AlCl₃ / CH₂Cl₂ / 1 h / 18 °C

With copper(l) iodide; aluminium trichloride; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; acetonitrile; 1: Sonogashira coupling;
DOI:10.1021/jm020077t

Reference yield:

: 215715-43-8
β,β-dibromo-3-isopropoxy-4-methoxystyrene

: 330666-86-9
2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / n-Butyllithium / hexane; tetrahydrofuran / -78 - 20 °C / Heating

2: Et₃N; CuI / Pd(PPh₃)2Cl₂ / acetonitrile / 1 h / 18 °C

3: 73 percent / K₂CO₃ / acetonitrile / 18 h / 18 °C

4: 91 percent / AlCl₃ / CH₂Cl₂ / 1 h / 18 °C

With copper(l) iodide; n-butyllithium; aluminium trichloride; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; 2: Sonogashira coupling;
DOI:10.1021/jm020077t