215715-43-8

Basic information

• Product Name: β,β-dibromo-3-isopropoxy-4-methoxystyrene
• Synonyms: β,β-dibromo-3-isopropoxy-4-methoxystyrene
• CAS NO: 215715-43-8
• Molecular Weight: 350.05
• Mol File: 215715-43-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: β,β-dibromo-3-isopropoxy-4-methoxystyrene(CAS DataBase Reference)
• NIST Chemistry Reference: β,β-dibromo-3-isopropoxy-4-methoxystyrene(215715-43-8)
• EPA Substance Registry System: β,β-dibromo-3-isopropoxy-4-methoxystyrene(215715-43-8)

Safety Data

• Hazardous Substances Data: 215715-43-8(Hazardous Substances Data)

Upstream product

• 558-13-4 carbon tetrabromide 
• 34123-66-5 O-isopropylisovanillin 
• 621-59-0 isovanillin 

Downstream Products

• 334708-38-2 benzyl 2-[2'-(3''-isopropoxy-4''-methoxyphenyl)-ethynyl]-5-methoxyphenyl sulfide 
• 439585-86-1 4-ethynyl-2-isopropoxy-1-methoxybenzene 
• 1108621-60-8 2-(2-(3-isopropoxy-4-methoxystyryl)-4-isopropoxy-5-methoxyphenyl)ethoxime 
• 1108621-62-0 1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline-N-hydroxide 
• 1108621-35-7 (Z)-2-[-2-(3-isopropoxy-4-methoxystyryl)-4-isopropoxy-5-methoxyphenyl]-N-hydroxyethanamine 
• 1108621-37-9 (Z)-2-[2-(3-isopropoxy-4-methoxystyryl)-4-isopropoxy-5-methoxyphenyl]-N-hydroxy-2-methylprop-2-en-1-amine 
• 13168-51-9 N-benzoyl-norreticuline 
• 1108621-45-9 1-(3-isopropoxy-4-methoxybenzyl)-1,2,3,4-tetrahydro-7-isopropoxy-6-methoxyisoquinoline 
• 1108621-53-9 4-isopropoxy-2-[2-(3-isopropoxy-4-methoxyphenyl)ethynyl]-5-methoxybenzaldehyde 
• 218903-30-1 6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxy-3-(3'',4'',5''-trimethoxyphenyl)benzofuran 
• 218903-35-6 3-iodo-6-isopropoxy-2-(3'-isopropoxy-4'-methoxyphenyl)-5-methoxybenzofuran 
• 439585-92-9 2-(3′-isopropoxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole 
• 330666-86-9 2-(3′-hydroxy-4′-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole 
• 439585-90-7 6-methoxy-2-(3-isopropoxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)indole 

Relevant articles and documents

Studies on difficult intramolecular hydroaminations in the context of four syntheses of alkaloid natural products

Examples of intramolecular alkene hydroaminations forming six-membered ring systems are rare, especially for systems in which the double bond is disubstituted. Such cyclizations have important synthetic relevance. Herein we report a systematic study of these cyclizations using recently developed Cope-type hydroamination methodologies. Difficult intramolecular alkene hydroaminations were used as key steps in syntheses of 2-epi-pumiliotoxin C, coniine, N-norreticuline and desbromoarborescidine A. This effort required the development of optimized hydroamination conditions to improve the efficiency of the cyclizations. Collectively, our results show that Cope-type cyclizations can be achieved on a variety of challenging substrates and proceed under similar conditions for both N-H and N-substituted hydroxylamines.

The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4

A series of aryl- and aroyl-substituted chalcone analogues of the tubulin binding agent combretastatin A4 (1) were prepared, using a recently introduced one-pot palladium-mediated hydrostannylation-coupling reaction sequence. These chalcones were converte

Synthesis, X-Ray Crystal Structure and Tubulin-Binding Properties of a Benzofuran Analogue of the Potent Cytotoxic Agent Combretastatin A4

The benzofuran (4), a ring-fused analogue of the potent antimitotic agent combretastatin A4 (1), has been prepared by a convergent route involving 5-endo-dig iodocyclization of o-hydroxytolan (5) as the key step. Compound (4), which has been characterized crystallographically as well as spectroscopically, is inactive as a tubulin-binding agent.