(2′S)-2-Methoxymethyl-1-((2R)-2-methyl-1-phenylbutylidenamino)pyrrolidine

Base Information

Chemical Name:(2′S)-2-Methoxymethyl-1-((2R)-2-methyl-1-phenylbutylidenamino)pyrrolidine
CAS No.:91739-22-9
Molecular Formula:C₁₇H₂₆N₂O
Molecular Weight:274.406
Hs Code.:

Synonyms:(2′S)-2-Methoxymethyl-1-((2R)-2-methyl-1-phenylbutylidenamino)pyrrolidine

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Chemical Property of (2′S)-2-Methoxymethyl-1-((2R)-2-methyl-1-phenylbutylidenamino)pyrrolidine

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Technology Process of (2′S)-2-Methoxymethyl-1-((2R)-2-methyl-1-phenylbutylidenamino)pyrrolidine

There total 5 articles about (2′S)-2-Methoxymethyl-1-((2R)-2-methyl-1-phenylbutylidenamino)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: (2S)-2-Methoxymethyl-1-(1-phenylbutylidenamino)pyrrolidine

: 91739-22-9
(2′S)-2-Methoxymethyl-1-((2R)-2-methyl-1-phenylbutylidenamino)pyrrolidine

Guidance literature:: (2S)-2-Methoxymethyl-1-(1-phenylbutylidenamino)pyrrolidine; With n-butyllithium; diisopropylamine; In diethyl ether; cyclohexane; at -110 ℃; for 4.25h;

With methyl iodide; In diethyl ether; water; at 20 ℃;
DOI:10.1021/acs.organomet.7b00410

Reference yield: 90.0%

: 91658-11-6,91658-38-7
(+)-(S)-2-methoxymethyl-1-(1-phenylbutylideneamino)-pyrrolidine

: 74-88-4
methyl iodide

: 91739-22-9
(2′S)-2-Methoxymethyl-1-((2R)-2-methyl-1-phenylbutylidenamino)pyrrolidine

Guidance literature:: With n-butyllithium; diisopropylamine; In diethyl ether; hexane; 0 degC, 15 min then -110 degC then allowed to reach room temperature;
DOI:10.1016/S0040-4020(01)82420-0

Reference yield:

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 91739-22-9
(2′S)-2-Methoxymethyl-1-((2R)-2-methyl-1-phenylbutylidenamino)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / benzene / 144 h / Heating

2: 90 percent / n-BuLi, diisopropylamine / hexane; diethyl ether / 0 degC, 15 min then -110 degC then allowed to reach room temperature

With n-butyllithium; diisopropylamine; In diethyl ether; hexane; benzene;
DOI:10.1016/S0040-4020(01)82420-0