(4-phosphonooxyphenyl)acetic acid 4'-[2-[1-(2,6-dichlorophenyl)-1-methylethyl]-4-(1-hydroxy-1-methylethyl)imidazol-1-yl]-3,3'-difluoro-5-methanesulfonylbiphenyl-4-ylmethyl ester

Base Information

Chemical Name:(4-phosphonooxyphenyl)acetic acid 4'-[2-[1-(2,6-dichlorophenyl)-1-methylethyl]-4-(1-hydroxy-1-methylethyl)imidazol-1-yl]-3,3'-difluoro-5-methanesulfonylbiphenyl-4-ylmethyl ester
CAS No.:1401907-56-9
Molecular Formula:C₃₇H₃₅Cl₂F₂N₂O₉PS
Molecular Weight:823.635
Hs Code.:

(4-phosphonooxyphenyl)acetic acid 4'-[2-[1-(2,6-dichlorophenyl)-1-methylethyl]-4-(1-hydroxy-1-methylethyl)imidazol-1-yl]-3,3'-difluoro-5-methanesulfonylbiphenyl-4-ylmethyl ester

Synonyms:(4-phosphonooxyphenyl)acetic acid 4'-[2-[1-(2,6-dichlorophenyl)-1-methylethyl]-4-(1-hydroxy-1-methylethyl)imidazol-1-yl]-3,3'-difluoro-5-methanesulfonylbiphenyl-4-ylmethyl ester

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Chemical Property of (4-phosphonooxyphenyl)acetic acid 4'-[2-[1-(2,6-dichlorophenyl)-1-methylethyl]-4-(1-hydroxy-1-methylethyl)imidazol-1-yl]-3,3'-difluoro-5-methanesulfonylbiphenyl-4-ylmethyl ester

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Technology Process of (4-phosphonooxyphenyl)acetic acid 4'-[2-[1-(2,6-dichlorophenyl)-1-methylethyl]-4-(1-hydroxy-1-methylethyl)imidazol-1-yl]-3,3'-difluoro-5-methanesulfonylbiphenyl-4-ylmethyl ester

There total 4 articles about (4-phosphonooxyphenyl)acetic acid 4'-[2-[1-(2,6-dichlorophenyl)-1-methylethyl]-4-(1-hydroxy-1-methylethyl)imidazol-1-yl]-3,3'-difluoro-5-methanesulfonylbiphenyl-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401907-76-3
(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetate

: 1401907-56-9
(4-phosphonooxyphenyl)acetic acid 4'-[2-[1-(2,6-dichlorophenyl)-1-methylethyl]-4-(1-hydroxy-1-methylethyl)imidazol-1-yl]-3,3'-difluoro-5-methanesulfonylbiphenyl-4-ylmethyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 0.25h;

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1401907-56-9
(4-phosphonooxyphenyl)acetic acid 4'-[2-[1-(2,6-dichlorophenyl)-1-methylethyl]-4-(1-hydroxy-1-methylethyl)imidazol-1-yl]-3,3'-difluoro-5-methanesulfonylbiphenyl-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-tetrazole / dichloromethane; acetonitrile / 3 h / 25 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 0 °C

2.2: pH 2 / Cooling with ice

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 0.25 h / 20 °C

With 1H-tetrazole; dmap; water; hydrogen; dicyclohexyl-carbodiimide; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 948843-02-5
methyl 2-(4-((bis(benzyloxy)phosphoryl)oxy)phenyl)acetate

: 1401907-56-9
(4-phosphonooxyphenyl)acetic acid 4'-[2-[1-(2,6-dichlorophenyl)-1-methylethyl]-4-(1-hydroxy-1-methylethyl)imidazol-1-yl]-3,3'-difluoro-5-methanesulfonylbiphenyl-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 0 °C

1.2: pH 2 / Cooling with ice

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 0.25 h / 20 °C

With dmap; water; hydrogen; dicyclohexyl-carbodiimide; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;