(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetate

Base Information

Chemical Name:(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetate
CAS No.:1401907-76-3
Molecular Formula:C₅₁H₄₇Cl₂F₂N₂O₉PS
Molecular Weight:1003.88
Hs Code.:

(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetate

Synonyms:(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetate

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Chemical Property of (4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetate

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Technology Process of (4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetate

There total 4 articles about (4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1256918-39-4
2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3‘-difluoro-4’-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol

: 256656-75-4
2-(4-((bis(benzyloxy)phosphoryl)oxy)phenyl)acetic acid

: 1401907-76-3
(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1401907-76-3
(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-tetrazole / dichloromethane; acetonitrile / 3 h / 25 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 0 °C

2.2: pH 2 / Cooling with ice

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 20 °C

With 1H-tetrazole; dmap; water; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1401907-76-3
(4'-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-4-(2-hydroxypropan-2-yl)-1H-imidazol-1-yl)-3,3'-difluoro-5-(methylsulfonyl)biphenyl-4-yl)methyl 2-(4-(bis(benzyloxy)phosphoryloxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-tetrazole / dichloromethane; acetonitrile / 3 h / 25 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 0 °C

2.2: pH 2 / Cooling with ice

3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 20 °C

With 1H-tetrazole; dmap; water; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;