3R,4S)-1-(tert-butoxycarbonyl)-4-(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid

Base Information

Chemical Name:3R,4S)-1-(tert-butoxycarbonyl)-4-(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid
CAS No.:1312350-23-4
Molecular Formula:C₁₇H₂₄N₂O₅
Molecular Weight:336.388
Hs Code.:

Synonyms:(3R,4S)-1-(tert-butoxycarbonyl)-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid

Suppliers and Price of 3R,4S)-1-(tert-butoxycarbonyl)-4-(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3R,4S)-1-(tert-butoxycarbonyl)-4-(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 3R,4S)-1-(tert-butoxycarbonyl)-4-(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid

There total 20 articles about 3R,4S)-1-(tert-butoxycarbonyl)-4-(1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: trans-1-(1,1-dimethylethyl) 3-ethyl 4-(1-methyl-2-oxo-1,2-dihydro-4-pyridinyl)-1,3-piperidinedicarboxylate

: 1312350-23-4
(3R,4S)-1-(tert-butoxycarbonyl)-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; for 16h;
DOI:10.1016/j.bmcl.2011.05.013

Reference yield:

: 1194488-90-8
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

: 1312350-23-4
(3R,4S)-1-(tert-butoxycarbonyl)-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / propan-1-ol; water / 14 h / 8 °C

2: methanol; magnesium / 2 h / Sonication

3: sodium ethanolate / ethanol / 16 h / 80 °C

4: sodium iodide / acetonitrile / 72 h / 45 °C

5: chiral AD column / ethanol; hexane; isopropyl alcohol / Resolution of racemate

6: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium ethanolate; sodium carbonate; magnesium; sodium iodide; lithium hydroxide; In tetrahydrofuran; methanol; propan-1-ol; ethanol; hexane; water; isopropyl alcohol; acetonitrile; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.05.013

Reference yield:

: 176525-98-7
1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate

: 1312350-23-4
(3R,4S)-1-(tert-butoxycarbonyl)-4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)piperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 14 h / 80 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / propan-1-ol; water / 14 h / 8 °C

3: methanol; magnesium / 2 h / Sonication

4: sodium ethanolate / ethanol / 16 h / 80 °C

5: sodium iodide / acetonitrile / 72 h / 45 °C

6: chiral AD column / ethanol; hexane; isopropyl alcohol / Resolution of racemate

7: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium ethanolate; potassium acetate; sodium carbonate; magnesium; sodium iodide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; propan-1-ol; ethanol; hexane; water; isopropyl alcohol; acetonitrile; 1: Miyaura reaction / 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.05.013