1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate

Base Information

• Chemical Name: 1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate
• CAS No.: 176525-98-7
• Molecular Formula: C₁₄H₂₀F₃NO₇S
• Molecular Weight: 403.377
• Mol file: 176525-98-7.mol

Synonyms:1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate

Chemical Property of 1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate

Chemical Property:

Purity/Quality:

98% ,99% , ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate

There total 1 articles about 1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H14O3NC6H5 (41276-30-6) → 1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate (176525-98-7)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol; H₂O / 20 °C / 2585.74 Torr

2: aq. NaHCO₃; NaCl / CHCl₃ / 60 °C

3: DIPEA / CH₂Cl₂ / -78 °C

With hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium chloride; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; water;

DOI:10.1016/j.bmcl.2005.06.033

Reference yield: 100.0%

4-methylphenylboronic acid (5720-05-8) + 1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate (176525-98-7) → 1-tert-butyl 3-ethyl 4-(p-tolyl)-5,6-dihydropyridine-1,3(2H)-dicarboxylate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 4h; Inert atmosphere; Reflux;

Reference yield: 99.0%

2-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine (1206625-60-6) + 1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate (176525-98-7) → 6-[2-(2,6-dichloro-4-methyl-phenoxy)ethoxy]-5',6'-dihydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester 3'-ethyl ester (1265907-54-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 50 - 83 ℃; for 1.08333h; Inert atmosphere; Large scale reaction;

DOI:10.1021/jo102070e

upstream raw materials:

C₉H₁₄O₃NC₆H₅

Downstream raw materials:

1-tert-butyl 3-ethyl 4-triflate-5,6-dihydropyridine-1,3(2H)-dicarboxylate

4-(4-fluoro-phenyl)-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

1-(tert-butyl) 3-ethyl 4-(4-chlorophenyl)-5,6-dihydropyridine-1,3(2H)-dicarboxylate

1-(1,1-dimethylethyl) 3-ethyl 4-(3,4-dichlorophenyl)-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate