2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>-4-(ethoxymethyl)imidazole

Base Information

Chemical Name:2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>-4-(ethoxymethyl)imidazole
CAS No.:102152-23-8
Molecular Formula:C₂₅H₃₃N₃O₅
Molecular Weight:455.554
Hs Code.:

Synonyms:2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>-4-(ethoxymethyl)imidazole

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Chemical Property of 2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>-4-(ethoxymethyl)imidazole

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Technology Process of 2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>-4-(ethoxymethyl)imidazole

There total 8 articles about 2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>-4-(ethoxymethyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102151-52-0
2-<4-(benzyloxy)phenyl>-4-(hydroxymethyl)imidazole

: 102152-23-8
2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>-4-(ethoxymethyl)imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) thionyl chloride / 1.) RT, 21 h, 2.) reflux, 18 h

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 2585.7 Torr

3: 1.) NaH / 1.) Me₂SO, 60 deg C, 15 min, 2.) Me₂SO, 60 deg C, overnight

4: 10percent NaOH / 2 h / Heating

With sodium hydroxide; thionyl chloride; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00156a028

Reference yield:

: 102151-53-1
2-imidazole-4-carboxylic acid

: 102152-23-8
2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>-4-(ethoxymethyl)imidazole

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / NaH / dimethylformamide / 18 h

2: 51 percent / LAH, Na₂SO₄ / tetrahydrofuran

3: 1.) NaH / 1.) DMF, 30min, 2.) DMF, 18 h

4: 71 percent / H₂ / 10percent Pd/C / ethanol / 2585.7 Torr

5: 1.) NaH / 1.) Me₂SO, 60 deg C, 15 min, 2.) Me₂SO, 60 deg C, overnight

6: 10percent NaOH / 2 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium sulfate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00156a028

Reference yield:

: 102151-58-6
2-<4-(benzyloxy)phenyl>-4-(methoxymethyl)imidazole

: 102152-23-8
2-<4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>phenyl>-4-(ethoxymethyl)imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol / 2585.7 Torr

2: 1.) NaH / 1.) Me₂SO, 60 deg C, 15 min, 2.) Me₂SO, 60 deg C, overnight

3: 10percent NaOH / 2 h / Heating

With sodium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00156a028