(E)-4-(2-(4-chlorophenyl)-3-cyclohexyl-1-(4-(2-(dimethylamino)ethoxy)-phenyl)prop-1-enyl)phenyl-2,2-dimethylpropanoate

Base Information

Chemical Name:(E)-4-(2-(4-chlorophenyl)-3-cyclohexyl-1-(4-(2-(dimethylamino)ethoxy)-phenyl)prop-1-enyl)phenyl-2,2-dimethylpropanoate
CAS No.:1403783-39-0
Molecular Formula:C₃₆H₄₄ClNO₃
Molecular Weight:574.203
Hs Code.:

Synonyms:(E)-4-(2-(4-chlorophenyl)-3-cyclohexyl-1-(4-(2-(dimethylamino)ethoxy)-phenyl)prop-1-enyl)phenyl-2,2-dimethylpropanoate

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Chemical Property of (E)-4-(2-(4-chlorophenyl)-3-cyclohexyl-1-(4-(2-(dimethylamino)ethoxy)-phenyl)prop-1-enyl)phenyl-2,2-dimethylpropanoate

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Technology Process of (E)-4-(2-(4-chlorophenyl)-3-cyclohexyl-1-(4-(2-(dimethylamino)ethoxy)-phenyl)prop-1-enyl)phenyl-2,2-dimethylpropanoate

There total 3 articles about (E)-4-(2-(4-chlorophenyl)-3-cyclohexyl-1-(4-(2-(dimethylamino)ethoxy)-phenyl)prop-1-enyl)phenyl-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1403783-36-7
(E)-4-(2-(4-chlorophenyl)-3-cyclohexyl-1-(4-hydroxyphenyl)prop-1-enyl)phenyl-2,2-dimethylpropanoate

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 1403783-39-0
(E)-4-(2-(4-chlorophenyl)-3-cyclohexyl-1-(4-(2-(dimethylamino)ethoxy)-phenyl)prop-1-enyl)phenyl-2,2-dimethylpropanoate

Guidance literature:: With potassium carbonate; In water; acetone; for 5h; Reflux;
DOI:10.1016/j.tet.2012.08.089

Reference yield:

: 931-51-1
cyclohexylmagnesiumchloride

: 1403783-39-0
(E)-4-(2-(4-chlorophenyl)-3-cyclohexyl-1-(4-(2-(dimethylamino)ethoxy)-phenyl)prop-1-enyl)phenyl-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc(II) chloride / diethyl ether / 0.5 h / 0 °C

1.2: 17 h / 20 °C / Inert atmosphere

2.1: titanium tetrachloride; zinc / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: potassium carbonate / acetone; water / 5 h / Reflux

With titanium tetrachloride; potassium carbonate; zinc(II) chloride; zinc; In tetrahydrofuran; diethyl ether; water; acetone; 2.1: |McMurry Reaction;
DOI:10.1016/j.tet.2012.08.089

Reference yield:

: 87482-75-5
1-(4-chlorophenyl)-2-cyclohexylethan-1-one

: 1403783-39-0
(E)-4-(2-(4-chlorophenyl)-3-cyclohexyl-1-(4-(2-(dimethylamino)ethoxy)-phenyl)prop-1-enyl)phenyl-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: titanium tetrachloride; zinc / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

2: potassium carbonate / acetone; water / 5 h / Reflux

With titanium tetrachloride; potassium carbonate; zinc; In tetrahydrofuran; water; acetone; 1: |McMurry Reaction;
DOI:10.1016/j.tet.2012.08.089