(4R)-3-((2'R,4'E)-2'-methyl-4'-hexenoyl)-4-(phenylmethyl)-2-oxazolidinone

Base Information

Chemical Name:(4R)-3-((2'R,4'E)-2'-methyl-4'-hexenoyl)-4-(phenylmethyl)-2-oxazolidinone
CAS No.:104324-25-6
Molecular Formula:C₁₇H₂₁NO₃
Molecular Weight:287.359
Hs Code.:

Synonyms:(4R)-3-((2'R,4'E)-2'-methyl-4'-hexenoyl)-4-(phenylmethyl)-2-oxazolidinone

Suppliers and Price of (4R)-3-((2'R,4'E)-2'-methyl-4'-hexenoyl)-4-(phenylmethyl)-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R)-3-((2'R,4'E)-2'-methyl-4'-hexenoyl)-4-(phenylmethyl)-2-oxazolidinone

Chemical Property:

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Technology Process of (4R)-3-((2'R,4'E)-2'-methyl-4'-hexenoyl)-4-(phenylmethyl)-2-oxazolidinone

There total 4 articles about (4R)-3-((2'R,4'E)-2'-methyl-4'-hexenoyl)-4-(phenylmethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1577-20-4
(E)-hex-4-enoic acid

: 104324-25-6
(4R)-3-((2'R,4'E)-2'-methyl-4'-hexenoyl)-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) triethylamine, trimethylacetyl chloride; 2.) n-butyllithium / 1.) THF, 10 min, -78 deg C and 30 min, 0 deg C; 2.) hexane, THF, 30 min, 0 deg C

2: 1.) sodium hexamethyldisilylamide / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 4 h

With n-butyllithium; sodium hexamethyldisilazane; pivaloyl chloride; triethylamine;
DOI:10.1021/ja00281a049

Reference yield:

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 104324-25-6
(4R)-3-((2'R,4'E)-2'-methyl-4'-hexenoyl)-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 2 h / 135 - 140 °C

2: 1.) triethylamine, trimethylacetyl chloride; 2.) n-butyllithium / 1.) THF, 10 min, -78 deg C and 30 min, 0 deg C; 2.) hexane, THF, 30 min, 0 deg C

3: 1.) sodium hexamethyldisilylamide / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 4 h

With n-butyllithium; sodium hexamethyldisilazane; pivaloyl chloride; potassium carbonate; triethylamine;
DOI:10.1021/ja00281a049

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 104324-25-6
(4R)-3-((2'R,4'E)-2'-methyl-4'-hexenoyl)-4-(phenylmethyl)-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) triethylamine, trimethylacetyl chloride; 2.) n-butyllithium / 1.) THF, 10 min, -78 deg C and 30 min, 0 deg C; 2.) hexane, THF, 30 min, 0 deg C

2: 1.) sodium hexamethyldisilylamide / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 4 h

With n-butyllithium; sodium hexamethyldisilazane; pivaloyl chloride; triethylamine;
DOI:10.1021/ja00281a049