N-(2-diphenylmethylamino-5-iodobenzoyl)-β-alanine ethyl ester

Base Information

• Chemical Name: N-(2-diphenylmethylamino-5-iodobenzoyl)-β-alanine ethyl ester
• CAS No.: 220650-90-8
• Molecular Formula: C₂₅H₂₅IN₂O₃
• Molecular Weight: 528.39
• Mol file: 220650-90-8.mol

Synonyms:N-(2-diphenylmethylamino-5-iodobenzoyl)-β-alanine ethyl ester

Chemical Property of N-(2-diphenylmethylamino-5-iodobenzoyl)-β-alanine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-diphenylmethylamino-5-iodobenzoyl)-β-alanine ethyl ester

There total 5 articles about N-(2-diphenylmethylamino-5-iodobenzoyl)-β-alanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

diphenylchloromethane (90-99-3) + 3-(2-amino-5-iodo)benzamidopropionic acid ethyl ester (151978-67-5) → N-(2-diphenylmethylamino-5-iodobenzoyl)-β-alanine ethyl ester (220650-90-8)

Guidance literature:

With 2,6-dimethylpyridine; In N,N-dimethyl-formamide; at 50 ℃; for 1h;

DOI:10.1016/S0968-0896(98)80013-8

Reference yield:

ethyl β-alaninate hydrochloride (4244-84-2) → N-(2-diphenylmethylamino-5-iodobenzoyl)-β-alanine ethyl ester (220650-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / triethylamine; DMAP / dimethylformamide

2: 56 percent / 2,6-lutidine / dimethylformamide / 1 h / 50 °C

With 2,6-dimethylpyridine; dmap; triethylamine; In N,N-dimethyl-formamide; 1: Acylation / 2: Alkylation;

DOI:10.1016/S0968-0896(98)80013-8

Reference yield:

5-iodoisatoic anhydride (116027-10-2) → N-(2-diphenylmethylamino-5-iodobenzoyl)-β-alanine ethyl ester (220650-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / triethylamine; DMAP / dimethylformamide

2: 56 percent / 2,6-lutidine / dimethylformamide / 1 h / 50 °C

With 2,6-dimethylpyridine; dmap; triethylamine; In N,N-dimethyl-formamide; 1: Acylation / 2: Alkylation;

DOI:10.1016/S0968-0896(98)80013-8

upstream raw materials:

diphenylchloromethane

3-(2-amino-5-iodo)benzamidopropionic acid ethyl ester

ethyl β-alaninate hydrochloride

5-iodoisatoic anhydride

Downstream raw materials:

8-[[4-cyanophenyl]ethynyl]-1-methyl-6-oxo-4H-imidazo[1,2-a][1,4]benzodiazepine-5(6H)-propanoic acid ethyl ester

1-(diphenylmethyl)-4-(2-carboxyethyl)-7-iodo-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione ethyl ester

7-[[4-cyanophenyl]ethynyl]-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione-4-propanoic acid ethyl ester