N-allyl-N-(2-iodoethyl)-4-hydroxymethylbenzenesulfonamide

Base Information

• Chemical Name: N-allyl-N-(2-iodoethyl)-4-hydroxymethylbenzenesulfonamide
• CAS No.: 1352740-92-1
• Molecular Formula: C₁₂H₁₆INO₃S
• Molecular Weight: 381.234
• Mol file: 1352740-92-1.mol

Synonyms:N-allyl-N-(2-iodoethyl)-4-hydroxymethylbenzenesulfonamide

Chemical Property of N-allyl-N-(2-iodoethyl)-4-hydroxymethylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-allyl-N-(2-iodoethyl)-4-hydroxymethylbenzenesulfonamide

There total 5 articles about N-allyl-N-(2-iodoethyl)-4-hydroxymethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-allyl-N-(2-iodoethyl)-4-formylbenzenesulfonamide (1352740-94-3) → N-allyl-N-(2-iodoethyl)-4-hydroxymethylbenzenesulfonamide (1352740-92-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201105235

Reference yield:

N-allyl-N-(2-iodoethyl)-4-cyanobenzenesulfonamide (1352740-89-6) → N-allyl-N-(2-iodoethyl)-4-hydroxymethylbenzenesulfonamide (1352740-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / hexane; toluene / 1 h / 0 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol; dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; diisobutylaluminium hydride; In methanol; hexane; dichloromethane; toluene;

DOI:10.1002/anie.201105235

Reference yield:

2-(allylamino)ethanol (2424-00-2) → N-allyl-N-(2-iodoethyl)-4-hydroxymethylbenzenesulfonamide (1352740-92-1)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: sodium iodide / acetone / 4 h / 60 °C / Inert atmosphere

3: diisobutylaluminium hydride / hexane; toluene / 1 h / 0 °C / Inert atmosphere

4: sodium tetrahydroborate / methanol; dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; diisobutylaluminium hydride; triethylamine; sodium iodide; In methanol; hexane; dichloromethane; acetone; toluene;

DOI:10.1002/anie.201105235

upstream raw materials:

N-allyl-N-(2-iodoethyl)-4-cyanobenzenesulfonamide

N-allyl-N-(2-iodoethyl)-4-formylbenzenesulfonamide

2-(allylamino)ethanol

tert-butyl-(prop-2-en-1-ylamino)-acetate

Downstream raw materials:

4-hydroxymethylphenylsulfonyl-3-methylenepyrrolidine