2424-00-2

Usage

Type of compound

Amino alcohol

Substituent group

Allyl group attached to the amino group

Usage

Raw material in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals

Industrial application

Solvent in certain industrial processes

Reaction potential

Can undergo hydroxylation, sulfation, and acetylation

Chemical versatility

Useful in a wide range of chemical applications

Chelating properties

Can act as a chelating agent

Metal ion interaction

Capable of forming complexes with metal ions

Importance

Serves as an important building block in the production of various chemicals with diverse applications in different industries.

Upstream product

• 141-43-5 ethanolamine 
• 106-95-6 allyl bromide 
• 107-11-9 1-amino-2-propene 
• 540-51-2 2-bromoethanol 
• 159675-32-8 tert-butyl-(prop-2-en-1-ylamino)-acetate 
• 75-21-8 oxirane 
• 114947-88-5 allyl-carbamic acid-(2-chloro-ethyl ester) 

Downstream Products

• 17719-79-8 (N,N-diallyl)-2-aminoethanol 
• 1352740-89-6 N-allyl-N-(2-iodoethyl)-4-cyanobenzenesulfonamide 
• 1352740-90-9 N-allyl-N-(2-iodoethyl)-4-iodobenzenesulfonamide 
• 1352740-91-0 N-allyl-N-(2-iodoethyl)-2-bromobenzenesulfonamide 
• 1352741-01-5 2-bromophenylsulfonyl-3-methylenepyrrolidine 
• 1352740-92-1 N-allyl-N-(2-iodoethyl)-4-hydroxymethylbenzenesulfonamide 
• 1352741-02-6 4-hydroxymethylphenylsulfonyl-3-methylenepyrrolidine 
• 1352740-94-3 N-allyl-N-(2-iodoethyl)-4-formylbenzenesulfonamide 
• 1352740-99-8 4-cyanophenylsulfonyl-3-methylenepyrrolidine 
• 1352741-00-4 4-iodophenylsulfonyl-3-methylenepyrrolidine 
• 1352741-03-7 4-formylphenylsulfonyl-3-methylenepyrrolidine 
• 86553-34-6 Toluene-4-sulfonic acid 2-[allyl-(toluene-4-sulfonyl)-amino]-ethyl ester 
• 1065075-80-0 benzyl allyl(2-hydroxyethyl)carbamate 

Relevant academic research and scientific papers

MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE

The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease

Naphthalene-linked P2-P4 macrocycles within a tri-peptide-based acyl sulfonamide chemotype have been synthesized and found to inhibit HCV NS3 proteases representing genotypes 1a and 1b with single digit nanomolar potency. The pharmacokinetic profile of compounds in this series was optimized through structural modifications along the macrocycle tether as well as the P1 subsite. Ultimately a compound with oral bioavailability of 100% in rat, and a long half-life in plasma was obtained. However, compounds in this macrocyclic series exhibited cardiac effects in an isolated rabbit heart model and for this reason further optimization efforts were discontinued.

Synthesis of new 3-substituted 1,3-oxazolidine-2-thiones

Reaction of N-alkylsubstituted ethanolamines with carbon disulfide followed by reaction with benzoyl chloride afforded N-substituted oxazolidine-2-thiones.

Sequence-defined polymers via orthogonal allyl acrylamide building blocks

Biological systems have long recognized the importance of macromolecular diversity and have evolved efficient processes for the rapid synthesis of sequence-defined biopolymers. However, achieving sequence control via synthetic methods has proven to be a difficult challenge. Herein we describe efforts to circumvent this difficulty via the use of orthogonal allyl acrylamide building blocks and a liquid-phase fluorous support for the de novo design and synthesis of sequence-specific polymers. We demonstrate proof-of-concept via synthesis and characterization of two sequence-isomeric 10-mer polymers. 1H NMR and LCMS were used to confirm their chemical structure while tandem MS was used to confirm sequence identity. Further validation of this methodology was provided via the successful synthesis of a sequence-specific 16-mer polymer incorporating nine different monomers. This strategy thus shows promise as an efficient approach for the assembly of sequence-specific functional polymers.

Cobalt-catalyzed coupling of alkyl iodides with alkenes: Deprotonation of hydridocobalt enables turnover

Completing the cycle: Cobalt complexes I and II were found to catalyze intramolecular alkyl Heck-type coupling reactions of alkyl iodides to alkenes upon irradiation with visible light in the presence of a tertiary amine base. The use of base is key to the catalytic turnover. The compatibility of the method with a broad range of functional groups opens opportunities for synthesis. Copyright

Anthracycline analogs

Anthracycline analogs and their bioconjugates are useful as anticancer agents.

PHOSPHONOOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE

Quinazoline derivatives of formula (I) wherein A is 5-membered heteroaryl containing a nitrogen atom and one or two further nitrogen atoms; compositions containing them, processes for their preparation and their use in therapy.

New polyoxazolidines, process for preparing them and use thereof

New polyoxazolidines can be defined by means of the general formula: STR1 wherein R, R1, R2, R3, R4, R5, R6 and n have the meaning as reported in the specification. These polyoxazolidines are useful as crosslinking agents for moisture-hardening systems on the basis of polyisocyanates, acrylate polymers and polyepoxides, in compositions for coatings, sealant compositions and adhesive compositions.