4-(2-Allyl-phenyl)-3-(2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(2-Allyl-phenyl)-3-(2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester
• CAS No.: 223440-40-2
• Molecular Formula: C₂₁H₂₄N₂O₆
• Molecular Weight: 400.431

Synonyms:4-(2-Allyl-phenyl)-3-(2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property of 4-(2-Allyl-phenyl)-3-(2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

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Technology Process of 4-(2-Allyl-phenyl)-3-(2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

There total 3 articles about 4-(2-Allyl-phenyl)-3-(2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) + 4-(2-Allyl-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (223440-39-9) → 4-(2-Allyl-phenyl)-3-(2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (223440-40-2)

Guidance literature:

In benzene; Heating;

DOI:10.1039/a808594c

Reference yield:

o-allylbenzaldehyde (62708-42-3) → 4-(2-Allyl-phenyl)-3-(2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (223440-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / HCl / methanol / 15 h / Heating

2: 91 percent / benzene / Heating

With hydrogenchloride; In methanol; benzene;

DOI:10.1039/a808594c

Reference yield:

ethyl acetoacetate (141-97-9) → 4-(2-Allyl-phenyl)-3-(2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester (223440-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / HCl / methanol / 15 h / Heating

2: 91 percent / benzene / Heating

With hydrogenchloride; In methanol; benzene;

DOI:10.1039/a808594c

upstream raw materials:

3-chloro-3-oxopropanoic acid methyl ester

4-(2-Allyl-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

o-allylbenzaldehyde

ethyl acetoacetate

Downstream raw materials:

4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-3,4-dihydro-2H-pyrimidine-1,5-dicarboxylic acid 1-benzyl ester 5-ethyl ester

4-(2-Allyl-phenyl)-3-(2-diazo-2-methoxycarbonyl-acetyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

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