4-(4-nitrophenyl)-6-methyl-2-methoxy-3,4-dihydropyrimidine-5-carboxylic acid cyanoethyl ester

Base Information

• Chemical Name: 4-(4-nitrophenyl)-6-methyl-2-methoxy-3,4-dihydropyrimidine-5-carboxylic acid cyanoethyl ester
• CAS No.: 251930-31-1
• Molecular Formula: C₁₆H₁₆N₄O₅
• Molecular Weight: 344.327
• Mol file: 251930-31-1.mol

Synonyms:4-(4-nitrophenyl)-6-methyl-2-methoxy-3,4-dihydropyrimidine-5-carboxylic acid cyanoethyl ester

Chemical Property of 4-(4-nitrophenyl)-6-methyl-2-methoxy-3,4-dihydropyrimidine-5-carboxylic acid cyanoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-nitrophenyl)-6-methyl-2-methoxy-3,4-dihydropyrimidine-5-carboxylic acid cyanoethyl ester

There total 2 articles about 4-(4-nitrophenyl)-6-methyl-2-methoxy-3,4-dihydropyrimidine-5-carboxylic acid cyanoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

O-methylisourea hemisulfate (29427-58-5,24285-39-0) + 4-(4-nitrophenyl)-3-(2-cyanoethoxy)carbonyl-3-buten-2-one (166809-85-4) → 4-(4-nitrophenyl)-6-methyl-2-methoxy-3,4-dihydropyrimidine-5-carboxylic acid cyanoethyl ester (251930-31-1)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; at 95 - 100 ℃; for 20h;

DOI:10.1021/jm990612y

Reference yield:

O-methylisourea hemisulfate (29427-58-5,24285-39-0) + 4-(4-nitrophenyl)-3-(2-cyanoethoxy)carbonyl-3-buten-2-one (166809-85-4) → 2-methoxy-6-methyl-4-(4-nitro-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 2-cyano-ethyl ester (251930-31-1)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; at 85 - 90 ℃; for 5h;

DOI:10.1021/jm990200p

Reference yield: 100.0%

methyl chloroformate (79-22-1) + 4-(4-nitrophenyl)-6-methyl-2-methoxy-3,4-dihydropyrimidine-5-carboxylic acid cyanoethyl ester (251930-31-1) → 4-(4-nitrophenyl)-3-carbomethoxy-6-methyl-2-methoxy-3,4-dihydropyrimidine-5-carboxylic acid cyanoethoxy ester

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1021/jm990612y

upstream raw materials:

O-methylisourea hemisulfate

4-(4-nitrophenyl)-3-(2-cyanoethoxy)carbonyl-3-buten-2-one

Downstream raw materials:

5-(2-cyanoethoxycarbonyl)-1,6-dihydro-2-methoxy-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

3-[3-(4-methoxycarbonyl-4-phenyl-piperidin-1-yl)-propylcarbamoyl]-6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid

5-(cyanoethoxycarbonyl)-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-4-methyl-6-(4-nitrophenyl)-2-oxo-1,2,3,6-tetrahydropyrimidine