5-(2-cyanoethoxycarbonyl)-1,6-dihydro-2-methoxy-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

Base Information

• Chemical Name: 5-(2-cyanoethoxycarbonyl)-1,6-dihydro-2-methoxy-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine
• CAS No.: 251930-33-3
• Molecular Formula: C₂₃H₁₉N₅O₉
• Molecular Weight: 509.432

Synonyms:5-(2-cyanoethoxycarbonyl)-1,6-dihydro-2-methoxy-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

Chemical Property of 5-(2-cyanoethoxycarbonyl)-1,6-dihydro-2-methoxy-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-cyanoethoxycarbonyl)-1,6-dihydro-2-methoxy-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

There total 2 articles about 5-(2-cyanoethoxycarbonyl)-1,6-dihydro-2-methoxy-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-Nitrophenyl chloroformate (7693-46-1) + 2-methoxy-6-methyl-4-(4-nitro-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 2-cyano-ethyl ester (251930-31-1) → 5-(2-cyanoethoxycarbonyl)-1,6-dihydro-2-methoxy-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine (251930-33-3)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 10h;

DOI:10.1021/jm990200p

Reference yield:

4-(4-nitrophenyl)-3-(2-cyanoethoxy)carbonyl-3-buten-2-one (166809-85-4) → 5-(2-cyanoethoxycarbonyl)-1,6-dihydro-2-methoxy-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine (251930-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / ethanol / 5 h / 85 - 90 °C

2: 68 percent / aq. NaHCO₃ / CH₂Cl₂ / 10 h / 20 °C

With sodium hydrogencarbonate; In ethanol; dichloromethane; 1: Condensation / 2: Carboxylation;

DOI:10.1021/jm990200p

Reference yield:

3-[4-methoxycarbonyl-4-phenyl piperidin-1-yl]propylamine (166809-18-3) + 5-(2-cyanoethoxycarbonyl)-1,6-dihydro-2-methoxy-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine (251930-33-3) → 2-methoxy-1-[3-(4-methoxycarbonyl-4-phenyl-piperidin-1-yl)-propylcarbamoyl]-4-methyl-6-(4-nitro-phenyl)-1,6-dihydro-pyrimidine-5-carboxylic acid 2-cyano-ethyl ester

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jm990200p

upstream raw materials:

4-Nitrophenyl chloroformate

2-methoxy-6-methyl-4-(4-nitro-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid 2-cyano-ethyl ester

4-(4-nitrophenyl)-3-(2-cyanoethoxy)carbonyl-3-buten-2-one

Downstream raw materials:

3-[3-(4-methoxycarbonyl-4-phenyl-piperidin-1-yl)-propylcarbamoyl]-6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid

5-(cyanoethoxycarbonyl)-1-{N-[3-(4-methoxycarbonyl-4-phenylpiperidin-1-yl)propyl]carboxamido}-4-methyl-6-(4-nitrophenyl)-2-oxo-1,2,3,6-tetrahydropyrimidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 251930-33-3 5-(2-cyanoethoxycarbonyl)-1,6-dihydro-2-methoxy-4-methyl-6-(4-nitrophenyl)-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send