N-[2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Base Information

• Chemical Name: N-[2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine
• CAS No.: 1131736-61-2
• Molecular Formula: C₂₃H₂₀Cl₂N₄O₃
• Molecular Weight: 471.343
• Mol file: 1131736-61-2.mol

Synonyms:N-[2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Chemical Property of N-[2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine

There total 9 articles about N-[2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)aniline (1131736-60-1) + 6-chloro-10-ethoxypyrido[4,3-c]-1,6-naphthyridine (1131736-53-2) → N-[2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (1131736-63-4) + N-[2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (1131736-61-2)

Guidance literature:

With sodium t-butanolate; In tetrahydrofuran; at 85 ℃; for 1h;

Reference yield:

2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)aniline (1131736-60-1) + 6-chloro-10-ethoxypyrido[4,3-c]-1,6-naphthyridine (1131736-53-2) → N-[2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (1131736-61-2)

Guidance literature:

With sodium t-butanolate; In tetrahydrofuran; at 85 ℃;

DOI:10.1016/j.bmcl.2014.02.011

Reference yield:

2-ethoxyisonicotinic acid (91940-86-2) → N-[2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)phenyl]-10-ethoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (1131736-61-2)

Guidance literature:

Multi-step reaction with 7 steps

1: oxalyl dichloride / dichloromethane

2: triethylamine / dichloromethane

3: sec.-butyllithium / tetrahydrofuran / -78 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / 100 °C

5: sodium hexamethyldisilazane / tetrahydrofuran / 0 °C

6: trichlorophosphate / 100 °C / Microwave irradiation

7: sodium t-butanolate / tetrahydrofuran / 85 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sec.-butyllithium; sodium hexamethyldisilazane; sodium carbonate; triethylamine; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2014.02.011

upstream raw materials:

2,6-dichloro-4-(2-methyl-1,3-dioxolan-2-yl)aniline

6-chloro-10-ethoxypyrido[4,3-c]-1,6-naphthyridine

2-ethoxyisonicotinic acid

2-ethoxy-N,N-diisopropylisonicotinamide

Downstream raw materials:

6-[(4-acetyl-2,6-dichlorophenyl)amino]pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one

C₁₉H₁₄Cl₂N₄O₂

6-{[2,6-dichloro-4-(1-hydroxy-1-methylethyl)phenyl]amino}pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one