7-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

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Chemical Name:7-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol
CAS No.:492439-25-5
Molecular Formula:C₂₁H₁₇N₇O
Molecular Weight:383.412
Hs Code.:

Synonyms:7-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

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Chemical Property of 7-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

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Technology Process of 7-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

There total 15 articles about 7-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 492439-23-3
[7-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine

: 492439-25-5
7-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

Guidance literature:: With sodium thiomethoxide; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1021/jo026508x

Reference yield:

: 290332-96-6
ethyl α-azido-β-(4-methoxypyrid-3-yl)acrylate

: 492439-25-5
7-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 13 steps

1: 67 percent / o-xylene / 0.42 h / 170 °C

2: 94 percent / sodium hydride / dimethylformamide / 12 h / 20 °C

3: 93 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

4: 86 percent / MnO₂ / CH₂Cl₂ / 72 h / 20 °C

5: 85 percent / Na / ethanol / 72 h / -15 °C

6: 82 percent / CH₂Cl₂ / 24 h / 20 °C

7: 70 percent / Bu₄NF/SiO₂ / 0.03 h / microwave irradiation

8: 97 percent / tetrahydrofuran / 24 h / 50 °C

9: 95 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 2 h / 20 °C

10: 62 percent / tetrahydrofuran; diethyl ether / 2 h / -15 °C

11: 84 percent / dimethylformamide / 80 °C

12: 90 percent / K₂CO₃ / 2-methoxy-ethanol / 24 h / Heating

13: 83 percent / sodium thiomethoxide / dimethylformamide / 3 h / 80 °C

With manganese(IV) oxide; lithium hydroxide; lithium aluminium tetrahydride; sodium thiomethoxide; tetrabutyl ammonium fluoride; sodium; silica gel; sodium hydride; potassium carbonate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; 2-methoxy-ethanol; o-xylene; water; N,N-dimethyl-formamide; 6: Staudinger reaction;
DOI:10.1021/jo026508x

Reference yield:

: 290333-00-5
[4-methoxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanol

: 492439-25-5
7-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 86 percent / MnO₂ / CH₂Cl₂ / 72 h / 20 °C

2: 85 percent / Na / ethanol / 72 h / -15 °C

3: 82 percent / CH₂Cl₂ / 24 h / 20 °C

4: 70 percent / Bu₄NF/SiO₂ / 0.03 h / microwave irradiation

5: 97 percent / tetrahydrofuran / 24 h / 50 °C

6: 95 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 2 h / 20 °C

7: 62 percent / tetrahydrofuran; diethyl ether / 2 h / -15 °C

8: 84 percent / dimethylformamide / 80 °C

9: 90 percent / K₂CO₃ / 2-methoxy-ethanol / 24 h / Heating

10: 83 percent / sodium thiomethoxide / dimethylformamide / 3 h / 80 °C

With manganese(IV) oxide; lithium hydroxide; sodium thiomethoxide; tetrabutyl ammonium fluoride; sodium; silica gel; potassium carbonate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; 2-methoxy-ethanol; water; N,N-dimethyl-formamide; 3: Staudinger reaction;
DOI:10.1021/jo026508x