[7-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine

Base Information

Chemical Name:[7-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine
CAS No.:492439-23-3
Molecular Formula:C₂₂H₁₉N₇O
Molecular Weight:397.439
Hs Code.:

Synonyms:[7-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine

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Chemical Property of [7-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine

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Technology Process of [7-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine

There total 14 articles about [7-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 50-01-1
guanidine hydrochloride

: (E)-1-(9-Benzylamino-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-7-yl)-3-dimethylamino-propenone

: 492439-23-3
[7-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine

Guidance literature:: With potassium carbonate; In 2-methoxy-ethanol; for 24h; Heating;
DOI:10.1021/jo026508x

Reference yield:

: 290332-96-6
ethyl α-azido-β-(4-methoxypyrid-3-yl)acrylate

: 492439-23-3
[7-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine

Guidance literature:: Multi-step reaction with 12 steps

1: 67 percent / o-xylene / 0.42 h / 170 °C

2: 94 percent / sodium hydride / dimethylformamide / 12 h / 20 °C

3: 93 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

4: 86 percent / MnO₂ / CH₂Cl₂ / 72 h / 20 °C

5: 85 percent / Na / ethanol / 72 h / -15 °C

6: 82 percent / CH₂Cl₂ / 24 h / 20 °C

7: 70 percent / Bu₄NF/SiO₂ / 0.03 h / microwave irradiation

8: 97 percent / tetrahydrofuran / 24 h / 50 °C

9: 95 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 2 h / 20 °C

10: 62 percent / tetrahydrofuran; diethyl ether / 2 h / -15 °C

11: 84 percent / dimethylformamide / 80 °C

12: 90 percent / K₂CO₃ / 2-methoxy-ethanol / 24 h / Heating

With manganese(IV) oxide; lithium hydroxide; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium; silica gel; sodium hydride; potassium carbonate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; 2-methoxy-ethanol; o-xylene; water; N,N-dimethyl-formamide; 6: Staudinger reaction;
DOI:10.1021/jo026508x

Reference yield:

: 290333-00-5
[4-methoxy-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-methanol

: 492439-23-3
[7-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine

Guidance literature:: Multi-step reaction with 9 steps

1: 86 percent / MnO₂ / CH₂Cl₂ / 72 h / 20 °C

2: 85 percent / Na / ethanol / 72 h / -15 °C

3: 82 percent / CH₂Cl₂ / 24 h / 20 °C

4: 70 percent / Bu₄NF/SiO₂ / 0.03 h / microwave irradiation

5: 97 percent / tetrahydrofuran / 24 h / 50 °C

6: 95 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 2 h / 20 °C

7: 62 percent / tetrahydrofuran; diethyl ether / 2 h / -15 °C

8: 84 percent / dimethylformamide / 80 °C

9: 90 percent / K₂CO₃ / 2-methoxy-ethanol / 24 h / Heating

With manganese(IV) oxide; lithium hydroxide; tetrabutyl ammonium fluoride; sodium; silica gel; potassium carbonate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; 2-methoxy-ethanol; water; N,N-dimethyl-formamide; 3: Staudinger reaction;
DOI:10.1021/jo026508x