(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxamido)succinate

Base Information

Chemical Name:(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxamido)succinate
CAS No.:960510-42-3
Molecular Formula:C₃₀H₃₂ClN₅O₇
Molecular Weight:610.066
Hs Code.:

Synonyms:(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxamido)succinate

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Chemical Property of (R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxamido)succinate

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Technology Process of (R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxamido)succinate

There total 8 articles about (R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxamido)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 960510-41-2
6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxylic acid

: 4079-64-5
(R)-dibenzyl 2-aminosuccinate p-toluenesulfonic acid salt

: 960510-42-3
(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxamido)succinate

Guidance literature:: 6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

(R)-dibenzyl 2-aminosuccinate p-toluenesulfonic acid salt; With triethylamine; In N,N-dimethyl-formamide; for 16h;

Reference yield: 88.0%

: 4079-64-5
(R)-dibenzyl 2-aminosuccinate p-toluenesulfonic acid salt

: 960510-42-3
(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxamido)succinate

Guidance literature:: 6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

(R)-dibenzyl 2-aminosuccinate p-toluenesulfonic acid salt; With triethylamine; In N,N-dimethyl-formamide; for 16h;

Reference yield:

: 960510-37-6
5-amino-3,6-dichloropyrazine-2-carbonitrile

: 960510-42-3
(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxamido)succinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile / 16 h / 70 °C

2.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C

3.1: copper(ll) bromide / water / 17 h / 0 - 20 °C

4.1: caesium carbonate; trifuran-2-yl-phosphane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 16 h / 75 °C / Inert atmosphere

5.1: sodium periodate; ruthenium (IV) oxide monohydrate; sodium carbonate / water; acetonitrile; tetrachloromethane / 5.5 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 16 h

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium periodate; trifuran-2-yl-phosphane; ruthenium (IV) oxide monohydrate; hydrogen bromide; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper(ll) bromide; sodium nitrite; In 1,4-dioxane; tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile;