(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-5-cyano-3-morpholinopyrazine-2-carboxamido)succinate

Base Information

Chemical Name:(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-5-cyano-3-morpholinopyrazine-2-carboxamido)succinate
CAS No.:960510-43-4
Molecular Formula:C₃₄H₄₀N₆O₈
Molecular Weight:660.727
Hs Code.:

Synonyms:(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-5-cyano-3-morpholinopyrazine-2-carboxamido)succinate

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Chemical Property of (R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-5-cyano-3-morpholinopyrazine-2-carboxamido)succinate

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Technology Process of (R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-5-cyano-3-morpholinopyrazine-2-carboxamido)succinate

There total 8 articles about (R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-5-cyano-3-morpholinopyrazine-2-carboxamido)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 110-91-8,99108-56-2
morpholine

: 960510-42-3
(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxamido)succinate

: 960510-43-4
(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-5-cyano-3-morpholinopyrazine-2-carboxamido)succinate

Guidance literature:: at 70 ℃; for 2h;

Reference yield:

: 960510-41-2
6-(bis(2-methoxyethyl)amino)-3-chloro-5-cyanopyrazine-2-carboxylic acid

: 960510-43-4
(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-5-cyano-3-morpholinopyrazine-2-carboxamido)succinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 16 h

2.1: 2 h / 70 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

Reference yield:

: 960510-37-6
5-amino-3,6-dichloropyrazine-2-carbonitrile

: 960510-43-4
(R)-dibenzyl 2-(6-(bis(2-methoxyethyl)amino)-5-cyano-3-morpholinopyrazine-2-carboxamido)succinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetonitrile / 16 h / 70 °C

2.1: hydrogen bromide; sodium nitrite / water / 0.5 h / 0 °C

3.1: copper(ll) bromide / water / 17 h / 0 - 20 °C

4.1: caesium carbonate; trifuran-2-yl-phosphane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 16 h / 75 °C / Inert atmosphere

5.1: sodium periodate; ruthenium (IV) oxide monohydrate; sodium carbonate / water; acetonitrile; tetrachloromethane / 5.5 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 16 h

7.1: 2 h / 70 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium periodate; trifuran-2-yl-phosphane; ruthenium (IV) oxide monohydrate; hydrogen bromide; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper(ll) bromide; sodium nitrite; In 1,4-dioxane; tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile;