(E)-2-[[3,4-bis(difluoromethoxy)phenyl-1-oxo-2-propenyl]amino]-5-bromobenzoic acid

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Chemical Name:(E)-2-[[3,4-bis(difluoromethoxy)phenyl-1-oxo-2-propenyl]amino]-5-bromobenzoic acid
CAS No.:1164144-92-6
Molecular Formula:C₁₈H₁₂BrF₄NO₅
Molecular Weight:478.195
Hs Code.:

Synonyms:(E)-2-[[3,4-bis(difluoromethoxy)phenyl-1-oxo-2-propenyl]amino]-5-bromobenzoic acid

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Chemical Property of (E)-2-[[3,4-bis(difluoromethoxy)phenyl-1-oxo-2-propenyl]amino]-5-bromobenzoic acid

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Technology Process of (E)-2-[[3,4-bis(difluoromethoxy)phenyl-1-oxo-2-propenyl]amino]-5-bromobenzoic acid

There total 4 articles about (E)-2-[[3,4-bis(difluoromethoxy)phenyl-1-oxo-2-propenyl]amino]-5-bromobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1001289-39-9
5-bromo-2-[(carboxyacetyl)amino]benzoic acid

: 127842-54-0
3,4-bis-(difluoromethoxy)-benzaldehyde

: 1164144-92-6
(E)-2-[[3,4-bis(difluoromethoxy)phenyl-1-oxo-2-propenyl]amino]-5-bromobenzoic acid

Guidance literature:: With piperidine; In toluene; for 0.5h; Dean-Stark; Reflux;
DOI:10.1016/j.bmcl.2013.09.100

Reference yield:

: (E)-2-[[3-(3,4-bis(difluoromethoxy)phenyl)-1-oxo-2-propenyl]amino]-5-bromobenzoic acid piperidinium salt

: 1164144-92-6
(E)-2-[[3,4-bis(difluoromethoxy)phenyl-1-oxo-2-propenyl]amino]-5-bromobenzoic acid

Guidance literature:: With acetic acid; In methanol; water;

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1164144-92-6
(E)-2-[[3,4-bis(difluoromethoxy)phenyl-1-oxo-2-propenyl]amino]-5-bromobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

2: piperidine / toluene / 0.5 h / Dean-Stark; Reflux

With piperidine; potassium carbonate; In N,N-dimethyl-formamide; toluene; 2: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2013.09.100