3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

Base Information

Chemical Name:3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile
CAS No.:1600566-55-9
Molecular Formula:C₂₉H₁₈F₄N₆O
Molecular Weight:542.495
Hs Code.:

Synonyms:3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

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Chemical Property of 3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

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Technology Process of 3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

There total 9 articles about 3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1600566-56-0
(2,4-dichloro-3-(3-fluorophenyl)-8-methylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

: 1600566-55-9
3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; XPhos; In N,N-dimethyl acetamide; at 120 ℃; for 4.5h; Inert atmosphere;

Reference yield:

: 1121-86-4
1-Fluoro-3-iodobenzene

: 1600566-55-9
3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; copper(l) iodide / 1,4-dioxane / 20 °C / Inert atmosphere

2.1: sodium hydroxide / water / 0.17 h / 65 °C

3.1: trichlorophosphate / 1 h / 70 °C

3.2: 3 h / 105 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.02 h / -78 °C / Inert atmosphere

4.2: 1.17 h / -78 °C / Inert atmosphere

4.3: Inert atmosphere

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; XPhos / N,N-dimethyl acetamide / 4.5 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; n-butyllithium; caesium carbonate; sodium hydroxide; zinc; XPhos; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl acetamide; water;

Reference yield:

: 2-(3-fluorophenyl)malonic acid

: 1600566-55-9
3-(3-fluorophenyl)-6-(hydroxy(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methyl)-8-methylquinoline-2,4-dicarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 1 h / 70 °C

1.2: 3 h / 105 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.02 h / -78 °C / Inert atmosphere

2.2: 1.17 h / -78 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; XPhos / N,N-dimethyl acetamide / 4.5 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; zinc; XPhos; trichlorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl acetamide;