3-Pyridinecarboxamide, N-methoxy-N-methyl-6-(trifluoromethyl)-

Base Information

• Chemical Name: 3-Pyridinecarboxamide, N-methoxy-N-methyl-6-(trifluoromethyl)-
• CAS No.: 416852-53-4
• Molecular Formula: C9H9F3N2O2
• Molecular Weight: 234.17500
• Mol file: 416852-53-4.mol

Synonyms:N-methoxy-N-methyl-6-trifluoromethylnicotinamide;N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide;

Chemical Property of 3-Pyridinecarboxamide, N-methoxy-N-methyl-6-(trifluoromethyl)-

Chemical Property:

• PSA: 42.43000
• LogP: 1.73380

Purity/Quality:

95% ^*data from raw suppliers

N-METHOXY-N-METHYL-6-TRIFLUOROMETHYL-NICOTINAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxamide, N-methoxy-N-methyl-6-(trifluoromethyl)-

There total 7 articles about 3-Pyridinecarboxamide, N-methoxy-N-methyl-6-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 6-trifluoromethylnicotinic acid (231291-22-8) → N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide (416852-53-4)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 60h;

Reference yield: 92.0%

6-(trifluoromethyl)nicotinoyl chloride (358780-13-9) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide (416852-53-4)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

Reference yield: 79.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 5-bromo-2(trifluoromethyl)pyridine (436799-32-5) → N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide (416852-53-4)

Guidance literature:

With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90 ℃; for 1h; Sealed tube;

DOI:10.1080/00397911.2014.974610

upstream raw materials:

6-(trifluoromethyl)nicotinoyl chloride

N,O-dimethylhydroxylamine*hydrochloride

6-trifluoromethylnicotinic acid

6-bromo-N-methoxy-N-methylpyridine-3-carboxamide

Downstream raw materials:

1-[(6-trifluoromethyl)-pyridine-3-yl]ethan-1-one

(2,4-dichloro-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-methoxy-8-methylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol

(3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-8-fluoro-2-methoxyquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol