benzyl (2R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methylpropanoate

Base Information

• Chemical Name: benzyl (2R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methylpropanoate
• CAS No.: 173441-06-0
• Molecular Formula: C₂₀H₂₉NO₄
• Molecular Weight: 347.455

Synonyms:benzyl (2R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methylpropanoate

Chemical Property of benzyl (2R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (2R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methylpropanoate

There total 3 articles about benzyl (2R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(S)-2-[(1R,2R)-2-Benzyloxycarbonyl-1-(imidazole-1-carbothioyloxy)-propyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (173441-07-1) → benzyl (2R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methylpropanoate (173441-06-0)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 110 ℃; for 4h;

DOI:10.1248/cpb.43.1706

Reference yield:

Boc-L-Pro-H (69610-41-9,117625-90-8) → benzyl (2R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methylpropanoate (173441-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 18 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C

2: 59 percent / dioxane / 24 h / Ambient temperature

3: 81 percent / n-Bu₃SnH, 2,2'-azobis(isobutyronitrile) / toluene / 4 h / 110 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; toluene;

DOI:10.1248/cpb.43.1706

Reference yield:

benzyl (2R,3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-hydroxy-2-methylpropanoate (163768-51-2) → benzyl (2R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methylpropanoate (173441-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / dioxane / 24 h / Ambient temperature

2: 81 percent / n-Bu₃SnH, 2,2'-azobis(isobutyronitrile) / toluene / 4 h / 110 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In 1,4-dioxane; toluene;

DOI:10.1248/cpb.43.1706

upstream raw materials:

(S)-2-[(1R,2R)-2-Benzyloxycarbonyl-1-(imidazole-1-carbothioyloxy)-propyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Boc-L-Pro-H

benzyl (2R,3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-hydroxy-2-methylpropanoate

Downstream raw materials:

(S)-2-[(R)-2-((S)-2-Phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

(R)-2-Methyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-3-(S)-pyrrolidin-2-yl-propionamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 173441-06-0 benzyl (2R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methylpropanoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send