[5-(2-FURYL)-1-METHYL-1H-PYRAZOL-3-YL]METHANOL

Base Information

• Chemical Name: [5-(2-FURYL)-1-METHYL-1H-PYRAZOL-3-YL]METHANOL
• CAS No.: 876728-41-5
• Molecular Formula: C9H10 N2 O2
• Molecular Weight: 178.191
• Hs Code.: 2933199090
• Mol file: 876728-41-5.mol

Synonyms:[5-(2-FURYL)-1-METHYL-1H-PYRAZOL-3-YL]METHANOL;[5-(2-Furyl)-1-methyl-1H-pyrazol-3-yl]methanol 97%

Chemical Property of [5-(2-FURYL)-1-METHYL-1H-PYRAZOL-3-YL]METHANOL

Chemical Property:

• Vapor Pressure: 7.07E-05mmHg at 25°C
• Melting Point: 43-48
• Boiling Point: 329.6°C at 760 mmHg
• Flash Point: 153.1°C
• PSA: 51.19000
• Density: 1.28g/cm³
• LogP: 1.17240

Purity/Quality:

98%min ^*data from raw suppliers

[5-(2-Furyl)-1-methyl-1H-pyrazol-3-yl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [5-(2-FURYL)-1-METHYL-1H-PYRAZOL-3-YL]METHANOL

There total 3 articles about [5-(2-FURYL)-1-METHYL-1H-PYRAZOL-3-YL]METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-(ethoxycarbonyl)-5-(2-furyl)-1-methylpyrazole (104296-35-7) → [5-(furan-2-yl)-1-methyl-1H-pyrazol-3-yl]methanol (876728-41-5)

Guidance literature:

ethyl 5-(furan-2-yl)-1-methyl-1H-pyrazole-3-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 60 ℃; for 1h; Inert atmosphere;

With sodium hydroxide; water; at 0 - 20 ℃;

DOI:10.1021/jo801729p

Reference yield:

1-(2-furyl)-1-ethanone (1192-62-7,80145-44-4) → [5-(furan-2-yl)-1-methyl-1H-pyrazol-3-yl]methanol (876728-41-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C

2: 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 60 °C / Cooling with ice

With lithium aluminium tetrahydride; potassium tert-butylate; In tetrahydrofuran;

Reference yield:

ethyl 4-(furan-2-yl)-2,4-dioxobutyrate (36983-35-4) → [5-(furan-2-yl)-1-methyl-1H-pyrazol-3-yl]methanol (876728-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 60 °C / Cooling with ice

With lithium aluminium tetrahydride; In tetrahydrofuran;

upstream raw materials:

3-(ethoxycarbonyl)-5-(2-furyl)-1-methylpyrazole

1-(2-furyl)-1-ethanone

ethyl 4-(furan-2-yl)-2,4-dioxobutyrate

Downstream raw materials:

5-(furan-2-yl)-1-methyl-1H-pyrazole-3-carbaldehyde

3-bromomethyl-5-(2-furyl)-1-methyl-1H-pyrazole

Refernces

• 1、 Fustero, Santos,Roman, Raquel,Sanz-Cervera, Juan F.,Simon-Fuentes, Antonio,Bueno, Jorge,Villanova, Salvador. "Synthesis of new fluorinated tebufenpyrad analogs with acaricidal activity through regioselective pyrazole formation". experimental part. p. 8545 - 8552. Retrieved 2009/04/05.