C₂₄H₂₀FNO₆S

Base Information

• Chemical Name: C₂₄H₂₀FNO₆S
• CAS No.: 935684-46-1
• Molecular Formula: C₂₄H₂₀FNO₆S
• Molecular Weight: 469.49
• Mol file: 935684-46-1.mol

Synonyms:C₂₄H₂₀FNO₆S

Chemical Property of C₂₄H₂₀FNO₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₄H₂₀FNO₆S

There total 4 articles about C₂₄H₂₀FNO₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

methyl 3-{4-[N-(5-fluoro-2-iodophenyl)sulfamoyl]phenyl}propanoate (935684-38-1) + 4-ethynyl-4-hydroxycyclohexa-2,5-dien-1-one (935684-39-2) → C24H20FNO6S (935684-46-1)

Guidance literature:

With diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl acetamide; water; at 100 ℃; for 0.166667h; microwave irradiation;

DOI:10.1021/jm061163m

Reference yield:

methyl 3-[4-(chlorosulfonyl)-phenyl]propanoate (374537-95-8) → C24H20FNO6S (935684-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / pyridine / tetrahydrofuran / 25 °C

2: 48 percent / diisopropylamine / tetrakis(triphenylphosphine)palladium; copper iodide / N,N-dimethyl-acetamide; H₂O / 0.17 h / 100 °C / microwave irradiation

With pyridine; diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl acetamide; water; 2: Sonogashira reaction;

DOI:10.1021/jm061163m

Reference yield:

4,4-dimethoxycyclohexa-2,5-dienone (935-50-2) → C24H20FNO6S (935684-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / tetrahydrofuran / -78 - 20 °C

2: 48 percent / diisopropylamine / tetrakis(triphenylphosphine)palladium; copper iodide / N,N-dimethyl-acetamide; H₂O / 0.17 h / 100 °C / microwave irradiation

With diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl acetamide; water; 2: Sonogashira reaction;

DOI:10.1021/jm061163m

upstream raw materials:

methyl 3-{4-[N-(5-fluoro-2-iodophenyl)sulfamoyl]phenyl}propanoate

4-ethynyl-4-hydroxycyclohexa-2,5-dien-1-one

methyl 3-[4-(chlorosulfonyl)-phenyl]propanoate

4,4-dimethoxycyclohexa-2,5-dienone