1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-N,4-dimethyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

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Chemical Name:1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-N,4-dimethyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide
CAS No.:1574110-31-8
Molecular Formula:C₂₆H₂₈ClF₃N₂O
Molecular Weight:476.969
Hs Code.:

Synonyms:1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-N,4-dimethyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

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Chemical Property of 1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-N,4-dimethyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

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Technology Process of 1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-N,4-dimethyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

There total 6 articles about 1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-N,4-dimethyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 2314-97-8,263005-66-9
iodotrifluoromethane

: 1574118-31-2
1-benzyl-3-(4-chlorophenyl)-N,4-dimethyl-N-neopentyl-1H-pyrrole-2-carboxamide

: 1574110-31-8
1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-N,4-dimethyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: iodotrifluoromethane; 1-benzyl-3-(4-chlorophenyl)-N,4-dimethyl-N-neopentyl-1H-pyrrole-2-carboxamide; With ferrous(II) sulfate heptahydrate; In dimethyl sulfoxide; for 0.0333333h;

With dihydrogen peroxide; In water; dimethyl sulfoxide; for 0.25h;

Reference yield:

: 37629-52-0
(E)-1-(4-chlorophenyl)-2-nitropropene

: 1574110-31-8
1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-N,4-dimethyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,5,7-triazabicyclo-[4,4,0]-dec-5-ene(TBD) polystyrene / tetrahydrofuran; isopropyl alcohol / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

2.2: 20 °C

3.1: lithium hydroxide monohydrate; ethanol; water / tetrahydrofuran / 2 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / 1,2-dimethoxyethane / 1 h / Reflux

5.1: ferrous(II) sulfate heptahydrate / dimethyl sulfoxide / 0.03 h

5.2: 0.25 h

With ferrous(II) sulfate heptahydrate; lithium hydroxide monohydrate; ethanol; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 1574117-15-9
1-benzyl-3-(4-chlorophenyl)-4-methyl-1H-pyrrole-2-carboxylic acid

: 1574110-31-8
1-benzyl-3-(4-chlorophenyl)-N-(2,2-dimethyl-propyl)-N,4-dimethyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / 1,2-dimethoxyethane / 1 h / Reflux

2.1: ferrous(II) sulfate heptahydrate / dimethyl sulfoxide / 0.03 h

2.2: 0.25 h

With ferrous(II) sulfate heptahydrate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; dimethyl sulfoxide;