(R)-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)methanol

Base Information

Chemical Name:(R)-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)methanol
CAS No.:1365214-71-6
Molecular Formula:C₁₇H₁₇FN₄O
Molecular Weight:312.347
Hs Code.:

Synonyms:(R)-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)methanol

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Chemical Property of (R)-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)methanol

Chemical Property:

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Technology Process of (R)-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)methanol

There total 8 articles about (R)-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365214-67-0
(R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine-3-carboxylic acid

: 1365214-71-6
(R)-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 6775-78-6
6-chloroimidazo[1,2-b]pyridazine

: 1365214-71-6
(R)-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 °C

2.1: sodium hydroxide / water / 0.33 h

2.2: 72 h / 100 °C

3.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C / Microwave irradiation

4.1: sodium hydroxide; ethanol / Reflux

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With N-Bromosuccinimide; lithium aluminium tetrahydride; ethanol; sodium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 13526-66-4
3-bromo-6-chloro-imidazo[1,2-b]pyridazine

: 1365214-71-6
(R)-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 0.33 h

1.2: 72 h / 100 °C

2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 150 °C / Microwave irradiation

3.1: sodium hydroxide; ethanol / Reflux

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; ethanol; sodium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide;