N,N-Dimethyl-2-{3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenoxy}ethanamine

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Chemical Name:N,N-Dimethyl-2-{3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenoxy}ethanamine
CAS No.:1226917-08-3
Molecular Formula:C₂₄H₂₄F₃N₅O₃
Molecular Weight:487.481
Hs Code.:

Synonyms:N,N-Dimethyl-2-{3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenoxy}ethanamine

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Chemical Property of N,N-Dimethyl-2-{3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenoxy}ethanamine

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Technology Process of N,N-Dimethyl-2-{3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenoxy}ethanamine

There total 9 articles about N,N-Dimethyl-2-{3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenoxy}ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1225380-79-9
3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-phenol

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 1226917-08-3
N,N-Dimethyl-2-{3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenoxy}ethanamine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 48h;

Reference yield:

: 402-61-9
5-methyl-1H-pyrazole-3-carboxylic acid

: 1226917-08-3
N,N-Dimethyl-2-{3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenoxy}ethanamine

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 7 h / 20 - 140 °C

2: potassium tert-butylate / tetrahydrofuran / 15 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

With potassium tert-butylate; tetrabutyl ammonium fluoride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 7781-98-8
ethyl-3-hydroxybenzoate

: 1226917-08-3
N,N-Dimethyl-2-{3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenoxy}ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 0 - 20 °C

2: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 h / 20 °C

4: potassium tert-butylate / tetrahydrofuran / 15 h / 0 - 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

With 1H-imidazole; lithium aluminium tetrahydride; carbon tetrabromide; potassium tert-butylate; tetrabutyl ammonium fluoride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;